ECE2021 Audio Eposter Presentations Thyroid (157 abstracts)
Characteristics of medullary thyroid cancer in the Republic of Belarus and prognosis factors
Victor Kondratovich 1 , Tatiana Leonova 1 , Alla Shepelkevich 2 , Yuliya Dydyshka 2 , Alexandra Sosedkova 1 , Tatsiana Chakhovich 3 , Alina Shloma 3 , Sergey Smirnov 3 , Kseniya Ruksha 3 , Alena Subach 3 & Anna Portyanko 3
1Public Health Institution Minsk City Clinical Oncologic Dispensary, Belarus; 2Belarusian State Medical University, Department of Endocrinology, Belarus; 3N.N. Alexandrov National Cancer Centre of Belarus, National Molecular Genetics Centre of Cancer Research, Belarus
Background
Medullary thyroid cancer (MTC) is a calcitonin-producing C-cell tumor and accounts about 5% in the structure of thyroid malignancies. There are sporadic and hereditary variant of MTC, which is a mandatory component of endocrine neoplasia syndrome type 2. The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and demographic characteristics.
Materials and methods
The study is carried out of the state program “Oncological Diseases” on the assignment “To develop and implement effective technologies for the diagnostic detection and monitoring of patients with multiple endocrine neoplasia type 2a syndrome.” Patient inclusion criteria for the study: morphologically verified diagnosis of MTC, written informed patient’s consent, ability to follow instructions throughout the study.
Results
The data obtained from the Belarusian cancer-register during 1987–2017 years. The research included the information about 591 patients with MTC. The MTC incidence index in the Republic of Belarus is constant, makes 0.2 per 100 thousand population. The number of MTC cases increased by 3.6 times, annually increased from 5 to 30 cases. It is explained by the improvement of diagnostics’ quality and the of average population’s life expectancy. The increase of MTC incidence was observed after the age of 40 with subsequent increase by the age of 60. MTC was more often observed among women (71.1%), than among men (28.9%). The essential difference in incidence among city residents and villagers wasn’t revealed in the last decade. It confirms equal opportunities of diagnostics for the both of groups. The distribution of patients by region over the past 10 years has been uniform. There were 45.2 % patients with metastatic form of disease in this research, 44.8 % of them with neck lymph node metastases and 5 % had distant metastases. More common tumors were more often diagnosed in male. As a result of univariate analysis, prognostic factors influencing specific survival were revealed: male sex (P<0.05), extrathyroid tumor growth (P<0.001), the presence of metastases in regional lymph nodes (P<0.05) and distant metastases (P< 0.001).
Conclusions
The incidence rate of MTC in the Republic of Belarus has increased more than 6 times over the past 30 years (0.03 and 0.2 per 100 000 population). Male sex, extrathyroid tumor growth, the presence of metastases in regional lymph nodes, distant metastases are prognostically unfavorable factors for the specific survival of patients with MTC.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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