Endocrine Abstracts

It is well known that the range of disorders of various organs and systems in thyroid dysfunction is diverse, due to the scale of the impact of thyroid hormones on the body. One of the most characteristic clinical manifestations of thyrotoxicosis is changes in the gastrointestinal tract in the form of dysbiosis. Some studies have found inconsistencies in the association of these filotypes with the presence of thyrotoxicosis. In addition, there is no data in the literature on the change in the content of the main filotypes of the intestinal microbiota depending on the state of compensation of thyrotoxicosis.

The purpose of the work was to study the species composition and population level of microflora of the intestinal cavity in patients with diffuse toxic goiter, as well as to study the content of the main filotypes of intestinal microbiota in these patients.

Material and methods

We examined 40 patients with accidents (15 men and 25 women) aged 30 to 73 years (mean age 47.8 + 8.9 years) in the stage of compensation and decompensation of the disease and 51 almost healthy donor who formed the control group. The first group (20 patients) consisted of patients in a state of compensation, the second group (20 patients) – in a state of decompensation of the disease.

Results and discussion

Analysis of changes in the species composition and population level of the microflora of intestinal cavity made it possible to establish that in all examined patients with accidents revealed intestinal dysbiosis. Grade IV dysbiosis was found in 27.5% patients, grade III dysbiosis in 22.5% patients, grade II dysbiosis in 18 patients 45% and grade I dysbiosis in 5% patients. Imbalance developed due to elimination and deficiency of autochthonous anaerobic and aerobic obligatory bacteria (Bifidobacteria, Lactobacteria and Enterococci), contamination of the large intestine with hemolytic Escherichia, opportunistic pathogenic enterobacteria, life expectancy and increase in staphylococci and yeast-like fungi of the Candida type.

Conclusion

Thus, the content of Firmicutes in patients with accidents was significantly higher, and the content of Bacteroidetes – significantly lower than in healthy individuals (P<0.05). Analyzing the content of the main microbial filotypes depending on the state of accident compensation, it was found that in patients in state of compensation and decompensation of accident the content of Firmicutes was significantly higher (P<0.05) and the content of Bacteroides – significantly lower in patients in the state of compensation and healthy individuals (P<0.05).