ECE2021 Audio Eposter Presentations Reproductive and Developmental Endocrinology (55 abstracts)
Selected steroid hormones – their physiological effects and use in diagnostics and research
Michaela Duskova 1 , 2 , Lucie Kolatorova 2 , Markéta Šimková 1 , Monika Šrámková 2 , Maria Malíková 2 , lenka Horackova 2 , Jana Vítků 2 & Luboslav Starka 2
1Institute of Endocrinology, Department of Steroids and Proteofactors, Praha, Czech Republic; 2General University Hospital, Department of Medicine Strahov
The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First, we focus on specific aspects arising from the pre-analytical phase of steroid determination that need to be considered when planning sampling, whether for diagnostics or research. Then, we provide a brief summary of the characteristics and diagnostic relevance of several steroid hormones and/or their metabolites: (pregnenolone, 17a-hydroxy-pregnenolone, dehydroepiandrosterone, hydroxyderivatives of dehydroepiandrosterone, androstenedione, testosterone, estrone, estradiol, estriol, cortisol, cortisone), which in our institute are determined with validated LC–MS/MS methods. For these steroids, we also provide newly calculated reference values in fertile women according to the phase of their menstrual cycle.
Acknowledgements
This work was supported by a grant from the Health Ministry of the Czech Republic (MZČR – RVO (“Endokrinologický ústav – EÚ00023761”).
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Endocrine Abstracts
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