ECE2021 Audio Eposter Presentations Adrenal and Cardiovascular Endocrinology (80 abstracts)
Assessment of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma
Jie Li 1 , Jiaxin Zhang 1 , Guimei Yang 1 , Xintong Hou 1 , Dan Yang 1 , Jing Yang 1 , Yi Zhang 2 & Yunfeng Liu 1
1First Hospital of Shanxi Medical University, Department of Endocrinology, Taiyuan, China; 2Shanxi Medical University, Department of Pharmacology, Taiyuan, China
Backgrounds
The study aimed to explore the characteristics of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma(NFAI). And investigate the relationship between these factors and insulin resistance, islet beta cell function.
Methods
This study enrolled eight patients with nonfunctional adrenal incidentaloma and five healthy controls(HCs). These data were recorded including body measurements, blood biochemical indicators, and the body composition measured by double energy X-ray absorptiometry(DEXA) technique. In addition, blood glucose levels were indicated by flash glucose monitoring system, which better showed blood variability(GV) according to calculating related parameters and analyzinyg several period times including nocturnal, fasting, and postprandial periods. Furthermore, the correlation between glucolipid metabolism and insulin resistance, islet beta cell function were analyzed in the NFAI group.
Results
As compared with HCs, NFAI group showed higher BMI, larger waistline and wasist hip rate(WHR), and lower HDL-c(all P < 0.05). Besides, related indicators with regard to indicators of glucose metabolism and body fat distribution showed no significant difference compared with those of HCs. As for FGMS, all indices indicating GV were not found significant differences compared with those of HCs except lower PT1(the percentage of blood glucose values less than 3.9 mmol/l during the day). Furthermore, the correlation analysis revealed that HbA1c% and FINS were positively correlated with HOMA-IR index, while BMI, neck circumference and lean weight of trunk were negatively correlated with HOMA-β cell function( all P < 0.05).
Conclusion
Compered with HCs, there are abnormalities glucoliqid metabolism and fat distribution changes in patients with NFAI. And fat distribution affect function of islet cells.
| Parameters | NFAI | HCs | P value |
| BMI(kg/m2) | 26.44 ± 1.93 | 23.20 ± 1.82 | 0.012 |
| Waistline(cm) | 92.89 ± 5.61 | 75.56 ± 4.57 | 0.000 |
| Hipline(cm) | 102.15(101.28.103.78) | 94.50(91.50.102.55) | 0.127 |
| Wasist hip rate(WHR) | 0.89 ± 0.04 | 0.79 ± 0.02 | 0.000 |
| HDL-C(mmol/l) | 1.09 ± 0.23 | 1.63 ± 0.18 | 0.001 |
| PT1 | 1.05 ± 1.15 | 6.76 ± 5.98 | 0.031 |
| HOMA-IR | ||
| R value | P value | |
| HbA1c(%) | 0.771 | 0.025 |
| FINS(mmol/l) | 0.684 | 0.006 |
| HOMA-β | ||
| R value | P value | |
| BMI(kg/m2) | –0.890 | 0.003 |
| Neck circumference(cm) | –0.767 | 0.026 |
| Trunk lean mass(g) | –0.851 | 0.007 |
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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