ECE2021 Audio Eposter Presentations Reproductive and Developmental Endocrinology (55 abstracts)
Flow medicated dilation is associated with matrix metalloproteinase-2 in healthy postmenopausal women
Eleni Armeni 1 , Georgios Georgiopoulos 2 , Dimitrios Delialis 2 , Areti Augoulea 1 , Stavroula Paschou 1 , Nikoletta Mili 1 , Asimina Chondrou 1 , Efthymios Kouerinis 1 , Panagiota Chatzivasileiou 3 , Georgios Kaparos 3 , Makarios Eleftheriadis 1 , Kimon Stamatelopoulos 2 & Irene Lambrinoudaki 1
1Second Department of Obstetrics and Gynecology, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; 2Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece; 3Hormonal and Biochemical Laboratory, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Introduction
Menopausal transition has been associated with an increase in cardiovascular risk, which is possibly linked with the hormonal imbalance following ovarian senescence. Both insulin levels and circulating androgens (FAI) have been associated with endothelial dysfunction, through studies evaluating flow mediated dilation (FMD). We aimed to investigate whether the link between these hormones and FMD might be explained by markers of oxidative stress, like metalloproteinases -2 and -9 or the heat shock protein 60 (HSP60).
Methods
This study included a total of 159 apparently healthy postmenopausal women, retrieved from a University Menopause Clinic. Exclusion criteria included intake of anti-hypertensive or dyslipidemic medications or menopause hormone therapy during the last 6 months, as well as previously diagnosed peripheral vascular disease or cardiovascular disease. We performed a fasting venous blood sample for biochemical, hormonal assessment and evaluation of markers of oxidative stress and the heat shock protein. Sonographical assessment took place immediately thereafter in one session, including brachial artery tonometry and assessment of flow mediated dilation (FMD).
Results
Correlation analysis showed that mean FMD values were associated with FAI (r = -0.238, P-value = 0.010) as well as with insulin levels (r = -0.196, p-value=0.032). There was a borderline correlation between MMP2 values and FMD (r = 0.159, P-value 0.061), while MMP2 values correlated with log-transformed HSP60 (r = -0.237, P-value=0.011). Multivariable analysis showed that FMD values were associated with FAI and MMP2 levels (Model R2 14.2%, FAI b-coefficient = -0.354, P-value = 0.016; MMP2, b-coefficient = 0.286, P-value=0.029), but the effect of insulin was lost, in a model that also included age and menopausal age, SBP, body mass index. The results of the multivariable model remained significant after additional adjustment for log-transformed values of HSP60.
Conclusion
In this sample of postmenopausal women, values of FMD were independently associated with levels of free androgens and MMP2. The action of insulin on vascular endothelium seems to be mediated by MMP2. Further studies are needed to explore these findings.
Volume 73
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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