ECE2021 Audio Eposter Presentations Pituitary and Neuroendocrinology (113 abstracts)
Disease activity is associated with depression and anxiety in cushing’s syndrome during COVID-19 pandemic
Hamide Piskinpasa 1 , Seda Turgut 1 , Ozlem Karaarslan 2 , Evin Bozkur 1 , Ayşe Esen Pazır 1 , Naim Pamuk 1 , Ilkay Çakir 1 , Meral Mert 1 & Sema Ciftci Dogansen 1
1Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, Department of Endocrinology and Metabolism, Istanbul, Turkey; 2Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, Department of Psychiatry, Istanbul, Turkey
Purpose
To assess the depression and anxiety and their relationship with disease activity in patients with Cushing’s syndrome (CS) in the COVID-19 pandemic.
Material and methods
This is a cross-sectional study including 54 patients with CS (48 female/6 male). Beck Depression Inventory-II (BDI-II), State Trait Anxiety Inventory (STAI)-State, STAI-Trait were used to evaluate, scores and severity of depression, the current state of anxiety, and general anxiety, respectively. Patients with active CS (n = 10) were recorded as group 1, those who were still receiving glucocorticoid replacement therapy after surgery (n = 14) as group 2, and those in remission (n = 30) as group 3. The groups were compared in terms of parameters that could affect anxiety and depression scores. Correlation analyses were also performed.
Results
BDI-II scores were higher in group 1 than group 3 (P = 0.002), and STAI-State scores were higher in group 1 than group 2 (P = 0.03) while STAI-Trait scores and the other parameters were similar between the groups. Moderate and severe depression were detected in 60% of group 1, 25% in group 2, and 16% in group 3. High state anxiety was seen in 70% of patients in group 1, 50% in group 2, and 57% in group 3. There were positive correlations between BDI-II scores and disease activity (r = 0.438, P = 0.001), and STAI-State scores and disease activity (r = 0.297, P = 0.029).
Conclusion
Increased depression and state anxiety during the pandemic in patients with active CS suggested that psychiatric disorders may increase in those with a higher risk of severe COVID-19 disease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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