ECE2021 Audio Eposter Presentations Pituitary and Neuroendocrinology (113 abstracts)
Pituitary surgery in northern ireland: A twenty year retrospective population based analysis
Paul Benjamin Loughrey 1 , 2 , Stephanie Craig 1 , Brian Herron 3 , Stephen Cooke 4 , Philip Weir 4 , Debarata Bhattacharya 5 , Erin Sturdy 5 , Manuel Salto-Tellez 1 , 3 , Eileen Parkes 6 , Darragh McArt 1 , Marta Korbonits 7 , Steven Hunter 2 & Jacqueline James , 3 & 8
1Queen’s University Belfast, Patrick G Johnston Centre for Cancer Research, Belfast, United Kingdom; 2Royal Victoria Hospital, Regional Centre for Endocrinology and Diabetes, Belfast, United Kingdom; 3Royal Victoria Hospital, Department of Cellular Pathology, Belfast, United Kingdom; 4Royal Victoria Hospital, Department of Neurosurgery, Belfast, United Kingdom; 5Royal Victoria Hospital, Department of Neuroradiology, Belfast, United Kingdom; 6University of Oxford, Department of Oncology, Oxford, United Kingdom; 7Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Centre for Endocrinology, William Harvey Research Institute, London, United Kingdom; 8Queen’s University Belfast, Northern Ireland Biobank, Belfast, United Kingdom
In Northern Ireland, the sole tertiary referral centre for pituitary disease which includes neurosurgery and endocrinology for ~1.9 million people, is based in the Royal Victoria Hospital, Belfast. A retrospective study has been commenced to examine clinical, biochemical, histopathological and radiological data for all patients operated on across an approximately 20 year period in Northern Ireland. Ethical approval was obtained from the Northern Ireland Biobank (study number NIB18–0282). We present preliminary clinical and histopathological data on this Northern Ireland pituitary surgery population cohort. To date, a total of 704 pituitary samples have been identified between 2000 to mid 2019, an average of 35.9 surgeries per year. During this time there were maximum two operating pituitary surgeons. There were 20 procedures for 17 paediatric patients, with the most common diagnosis being craniopharyngioma (n = 6). A total of 684 procedures for 633 adult patients were undertaken, of which 285 patients were female and 348 were male. Average age of the entire adult cohort at resection was 53.3 years (SD ± 15.1 years), with average resection age 50.6 years for female and 55.5 years for male. 591 surgeries were completed for pituitary neuroendocrine tumours (PitNETs) (86%), diagnosed on the basis of combined clinical, histopathological and radiological assessment. The majority of these procedures were undertaken for non-functioning PitNETs (n = 390, 66%). Other operated PitNET pathologies included acromegaly/gigantism (n = 112, 19%), Cushing’s disease (n = 60, 10%), prolactinoma (n = 20, 3%) and thyrotropinoma (n = 7, 1%). Only two samples could not be completely characterized. There are seven patients known to have AIP mutations in this surgical cohort (1% of all patients). Other more frequent pathologies requiring surgical intervention or biopsy included craniopharyngioma (n = 27), Rathke’s cleft cyst (n = 17) and hypophysitis (n = 7). Rare diagnoses included paraganglioma (n = 1), meningioma (n = 1) and Non-Hodgkin’s B cell lymphoma (n = 1). There were two perioperative deaths (mortality rate 0.3%), both secondary to postoperative haemorrhage. In summary, from the beginning of the year 2000 to mid 2019 this Northern Ireland tertiary referral centre has averaged appoximately 36 adult pituitary procedures per year, the majority of which were undertaken for PitNETs (86%). Establishment of a pituitary database spanning nearly two decades will provide a valuable research resource suitable for integration with novel tissue based analysis and will assist in clinical service improvement to enhance our understanding of pituitary disease, particularly in Northern Ireland.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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