ECE2021 Audio Eposter Presentations Pituitary and Neuroendocrinology (113 abstracts)
Body composition and nuchal skinfold thickness in pediatric brain tumor patients
Junxiang Peng 1 , 2 , Svenja Boekhoff 1 , Maria Eveslage 3 , Brigitte Bison 4 , Panjarat Sowithayasakul 1 , 5 & Hermann Müller 1
1University Children’s Hospital, Car von Ossietzky University Oldenburg, Department of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg AöR, Oldenburg, Germany; 2Southern Medical University, Guangzhou, Department of Neurosurgery, Nanfang Hospital, China; 3University Münster, Institute of Biostatistics and Clinical Research, Germany; 4Augsburg Hospital, Department of Neuroradiology, Augsburg, Germany; 5Srinakharinwirot University, Department of Pediatrics, Bangkok, Thailand
Background
Obesity, cardiovascular disease (CVD), and relapse/progression have impact on prognosis in pediatric brain tumor (BT) patients.
Methods
In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI follow-up monitoring as a parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Furthermore, BMI, waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood-pressure (BP) were analysed.
Results
CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC. WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST correlated with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP. In multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased.
Conclusions
NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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