ECE2021 Audio Eposter Presentations General Endocrinology (51 abstracts)
Evaluation of serum levels of chemerin and resistin in patients with rheumatoid arthritis. Two adipokines at the crossroad between rheumatology and endocrinology
Emanuela Vasileva 1 , 2 , Teodora Stankova 3 , Anastas Batalov 1 , 4 , Boyan Nonchev 5 , 6 , Rositsa Karalilova 1.7 , Anelia Bivolarska 8 & Radiana Staynova 9
1Medical University – Plovdiv, Propedeutics of Internal Diseases, Plovdiv, Bulgaria; 2UMHAT Kaspela, Clinic of Endocrinology and Metabolic Diseases, Plovdiv, Bulgaria; 3Medical University – Plovdiv, Department of Medical Biochemistry, Plovdiv, Bulgaria; 4UMHAT Kaspela, Clinic of Rheumatology, Plovdiv, Bulgaria; 5Medical University – Plovdiv, Department of Endocrinology and metabolic diseases, Plovdiv, Bulgaria; 6University Hospital Kaspela, Clinic of Endocrinology and Metabolic Diseases, Plovdiv, Bulgaria; 7University Hospital Kaspela, Clinic of Rheumatology, Plovdiv, Bulgaria; 8Plovdiv, Department of Medical Biochemistry, Plovdiv, Bulgaria; 9Medical University – Plovdiv, Department of Pharmaceutical Sciences, Plovdiv, Bulgaria
Introduction
Adipose tissue is already considered as a metabolic active endocrine organ secreting numerous substances called adipokines. A growing body of evidence links two of these adipokines- chemerin and resistin, to the pathogenesis of rheumatoid arthritis (RA) based on their effect on vascular function and creating an environment of low grade inflammation. Nevertheless, the exact mechanism of how these molecules act on the target cells of joint elements are not fully understood.
Objective
The aim of this pilot study is to examine the association оf the serum concentrations of chemerin and resistin with clinical markers of inflammation and disease activity in patients with rheumatoid arthritis.
Methods
Serum was collected from 20 patients (17 women, 3 men) and another 31 cases with no joint diseases were included as controls (21 women, 10 men). The levels of chemerin and resistin were measured by enzyme-linked immunosorbent assay (ELISA). Antropometric parameters were evaluated with standart procedures in a fasting status (0800 h) in the entire cohort. Rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum level of uric acid (UA) were evaluated in the subgroup of 20 patients. Disease activity score was determined using the Disease Activity Score-28 for Rheumatoid Arthritis with ESR (DAS28-ESR).
Result
The serum concentration of resistin was significantly higher in RA patients (13.28 ± 6.18 ng/ml) than in the healthy controls (7.04 ± 2.09 ng/ml, P < 0.001). In contrast, there was no significant difference in chemerin levels between the patient and the control groups [247.0 (226.5–314.6) ng/ml vs. 228.8 (203.1–276.0) ng/ml, P > 0.05, respectively]. However, the serum chemerin concentration correlated positively with ESR (r = 0.649, P = 0.002), CRP (r = 0.546, P = 0.013), RF (r = 0.465, P = 0.039), and DAS28-ESR (r = 0.807, P < 0.001). In comparison, the serum level of resistin correlated positively only with CRP (r = 0.537, p 0.015), and DAS28-ESR index (r = 0.470, P = 0.037).
Conclusion
Taken together, these findings suggest that both chemerin and resistin might contribute to the inflammatory changes associated with RA, performing pro-inflammatory activity. The two adipokines might also serve as novel biomarkers for reflecting disease activity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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