Endocrine Abstracts

Introduction

Epidermal growth factors accelerate healing in lesions of trophic disorders.

Methods

This is a prospective study carried out between February and June 2019 in the endocrinology and metabolic diseases department, involving 6 patients admitted for diabetic foot progressing for more than 3 months without healing after conventional treatment. Having received the injections of growth factors of the EGF type.

Results

the sex ratio is 2, with an average age of 53 years (39–73), T2D is more representative at 67% with an average seniority of 16.5 years, all patients were unbalanced with an average HbA1c at 8.45%, degenerative complications are found in all our patients with an IRCT patient on dialysis. Foot lesions are mainly located on the sole of the foot with a type of plantar perforating disease complicated in 3 cases by osteitis, with an evolution ranging from 3 months to 2 years, on arteriopathic feet, classified stage IIIB and IIIC of the ’UT. The pre-treatment management consisted of a discharge and dressing adapted for each patient, a sorting of antibiotics and glycemic control. The patients received an average of 6 injections of EGF at the rate of 2 sessions per week, the average length of stay in hospital is 21 days. There was a case of over granulation causing treatment to be stopped. Complete granulation was obtained in 4 patients, with a mean total healing time of 80 days.

Conclusion

Growth factor injections considerably improved the healing and healing time of foot lesions in our patients and thus appears to be an asset in the management of diabetic foot.