Endocrine Abstracts

Introduction

The prevalence of diabetes and pre-diabetes is steadily increasing. It affects 3 new cases every 10 seconds and more than 6 million per year. Objective: to determine the risk factors associated with diabetes in an Algiers population not known to be diabetic but at high risk.

Methods

500 patients aged 40 and over consulting at the level of primary care structures, volunteers but at high risk of diabetes, are subjected to a questionnaire, then to screening by carrying out an OGTT, an HbA1c (HPLC), an SNSF. The sensitivity and specificity of HbA1c at different thresholds for the diagnosis of diabetes and pre-diabetes were studied by ROC curve. The diagnostic performance of HbA1c was assessed by the areas under the ROC curve (AUC) estimated by the DeLong method.

Result

Among the 500 patients studied 69% are women and 31% are men with a sex ratio of 2.22. Of which half of the cases aged between 45–54 years. 53.2% of patients present with dysglycemia: including 29.4% pre-diabetes: (6.8% moderate fasting hyperglycemia (HMJ), 22.6% (Glucose intolerance) and 23.8% diabetes mellitus. The risk factors associated with diabetes in our population in descending order are:

• Excess weight (BMI ≥ 25 kg/m²) (P < 0.001).

• Male sex. (p: 0.025).

• Age ≥ 45 years (p: 0.033).

• Maternal family history of diabetes mellitus. (P: 0.042)

• waist/hip ratio ≥ 0.85 (android type) in women (P: 0.043)

• high blood pressure (P: 0.045).

Conclusion

Diabetes mellitus is a major public health problem around the world. It is unfortunately associated with the development of serious complications, which have a significant impact on morbidity and mortality. Early diagnosis could reduce and delay these complications, so it is important to identify pre-diabetic conditions early so that prevention efforts can be implemented by targeting these populations, and thus help prevent or slow down. the progression of this condition to overt diabetes.