ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD
Bojan Mitrovic 1 , Vladimir Samardzic 2 , Zoran Gluvic 1 , Ratko Tomasevic 3 , Milan Obradovic 4 , Emina Sudar-Milovanovic 4 & Esma R. Isenovic 4
1Zemun Clinical Hospital, Department of Endocrinology, Diabetes and Medicine ITU, Zemun, Serbia; 2Zemun Clinical Hospital, Department of Endocrinology and Diabetes, Zemun, Serbia; 3Zemun Clinical Hospital, Department of Gastroenterology, Zemun, Serbia; 1’VINČA’ Institute of Nuclear Sciences- National Institute of the Republic of Serbia, Laboratory for radiobiology and molecular genetics, Belgrade, Serbia
Introduction
Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.
Material and methods
A case-control study involved 30 non-obese subjects (BMI 18.5–30 kg/m2), who suffered from T2DM for less than 5 years. Such subjects are regularly under treatment by metformin (M) and sulphonylurea (SU) derivates. Liver steatosis severity is determined by ultrasonography and presented as grades 1, 2, and 3 (initial, moderate, and advanced liver steatosis), respectively, according to Singh et al. criteria (Singh et al. Indian J Endocr Metab 2013;17: 990–5).
Results
In the observed population, 14 (47%), 11 (36%), and 5 (17%) subjects are determined to grade 1, 2, and 3 liver steatosis severity groups, respectively. The mean values of iron homeostasis markers have not differed from normal values. Liver steatosis severity grades positively correlated with serum ferritin levels, and this correlation is not revealed in the cases with serum iron and transferrin levels.
Conclusion
The low grade of liver steatosis has predominated in non-obese T2DM subjects under treatment with M and SU, irrespective of glycemic control quality. An increase in liver steatosis severity follows the ascending trend of ferritin levels. Further studies are needed to elucidate the impact of the quality of T2DM control on liver steatosis severity and iron metabolism markers.
Keywords: Non-alcoholic fatty liver disease, type 2 diabetes mellitus, ferritin
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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