Endocrine Abstracts

Background

Hormone replacement therapy is often used for hypopituitarism, which leads to dysglycemia. This study is conducted to assess the glucose metabolism conditions using the flash glucose monitoring system (FGMS) in patients with hormone replacement therapy.

Method

Seven patients who were diagnosed as hypopituitarism and treated with glucocorticoids and L-Thyroxine were qualified to participate in this study. These patients’ blood pressure, blood sugar, sodium ions and FT3, FT4 were normal after hormone replacement therapy. We also recruited five healthy volunteers responsible for normal controls. FGMS data were disposed from two perspectives. Firstly, parameters consist of 24-hour mean blood glucose (24 h MBG), standard deviation of blood glucose (SDBG), coefficient of variance (CV), mean of daily differences (MODD), time in range (TIR). Secondly, several time periods were analyzed specifically, including the whole day, nocturnal, fasting, and postprandial periods. All of these indexes were analyzed by a t-test or Mann-Whitney test.

Results

Compere with HCs, the indexes including 24hMBG (P = 0. 956), SDBG (P = 0. 056), CV (P = 0. 610), MODD (P = 0. 416) and TIR (P = 0. 59) had normal outcomes. There was no significantly different AUC was identified at the whole day (P = 0. 360); significantly different AUC was found at nocturnal period (3. 93 ± 0. 50vs4. 0 ± 0. 41, P = 0. 009), fasting period (4. 05 ± 0. 62vs4. 28 ± 0. 38, P = 0. 003), after breakfast (4. 77 ± 0. 64vs4. 80, 5. 95, P < 0. 001), after lunch (6. 11 ± 0. 93vs5. 86 ± 0. 42, P < 0. 001) and after dinner (5. 95 ± 0. 66vs4. 58, 6. 33, P = 0. 09).

Conclusion

Patients with hormone therapy had higher postprandial blood glucose than HCs. Because exogenous hormones cannot simulate the secretion rhythm of endogenous hormones. In addition, patient’s nocturnal blood glucose was low. Exogenous hormones had a short acting time, which can not maintain nocturnal blood glucose. On the other hand, exogenous hormones inhibited adrenal glands’ function, leading to the further lack of endogenous hormones and the low blood sugar level at night.