ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
The effect of obesity on the association between type 2 diabetes mellitus and polycystic ovary syndrome: a meta-analysis of observational studies
Panagiotis Anagnostis 1 , Rodis Paparodis 2 , Julia Bosdou 3 , Christina Bothou 4 , Djuro P. Macut 5 , Dimitrios Goulis 1 & Sarantis Livadas 6
1Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece; 2Center for Diabetes and Endocrine Research, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; 3Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zürich, Switzerland; 5Clinic for Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 6Endocrine Unit, Metropolitan Hospital, Athens, Greece
Objective
The exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.
Methods
A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases up to October 31, 2020. Data are expressed as relative risk (RR) with 95% confidence interval (CI). The I2 index was employed for heterogeneity. Research design and methods: The eligibility criteria were fulfilled by 23 studies (319.780 participants; 60.336 PCOS and 8847 type 2 diabetes cases). Women with PCOS demonstrated a higher risk of type 2 diabetes than those without PCOS (RR 3.45, 95% CI, 2.95–4.05, P < 0.001; I2 81.6%). This risk remained significant both in studies matched or unmatched for participants’ age. With regard to body mass index, the RR for developing type 2 diabetes in obese and non-obese PCOS women compared with their non-PCOS counterparts was 3.24 (95% CI 2.25–4.65; P < 0.001; I2 30.9%) and 1.62 (95% CI 0.14–18.50; P = 0.70; I2 89.9%), respectively. The RR in obese compared with non-obese women with PCOS was 3.85 (95% CI 1.99–7.43; P < 0.001; I2 46.2%). This was also the case for overweight compared with normal-weight women with PCOS.
Conclusion
Women with PCOS present an increased risk of type 2 diabetes compared with non-PCOS women only if they are obese/overweight.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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