ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Plasma angiopoietin-like 4 protein: Long term evolution after 3 different techniques of bariatric surgery
Guillermo Velasco de Cos 1 , Angela Gonzalez Diaz-Faes 2 , Armando Guerra Ruiz 1 , Ricardo Batanero Maguregui 2 , Elena Gonzalez Lopez 3 , Coral Montalbán Carrasco 2 , Bernardo Alio Lavín Gómez 1 , María Teresa García-Unzueta 1 & Luis Alberto Vázquez Salvi 2
1Hospital Universitario Marqués de Valdecilla, Análisis clínicos, Santander, Spain; 2Hospital Universitario Marqués de Valdecilla -Endocrinologia, Santander, Spain; 3Hospital Universitario Marqués de Valdecilla, Inmunología, Santander, Spain
Introduction
Angiopoietin-like 4 protein (ANGPTL-4) is importantly produced in adipose tissue, mediates the inhibition of lipoprotein-lipase and has been recently related with the risk of atherosclerosis and type 2 diabetes (T2D). Bariatric surgery has demonstrated improvements in lipid profile, T2D and cardiovascular risk. But information about ANGPTL-4 circulating levels in severe obesity and after bariatric surgery is scarce.
Objective
To evaluate the evolution of circulating ANGPTL-4 seven years after 3 different techniques of bariatric surgery and its relationship with improvement in lipid profile.
Results
ANGPTL-4 circulating levels and lipid profile were analyzed in 23 non-diabetic women (age 37.7 + 9.3) with severe obesity (BMI 48.9 ± 6.5 kg/m2) before and 6.9 ± 2.1 years after bariatric surgery: sleeve gastrectomy (n = 8), gastric bypass (n = 8) and biliopancreatic diversion (n = 7) (weight loss 42.0 ± 16.3 kg) as well as in 8 control lean women. ANGPTL -4 levels (ng/ml) decreased significantly (304.53 ± 48.75 pre vs 197.77 ± 64.10 post; P < 0.001; control 172.51 ± 28.01; P < 0.001 vs pre, and without differences with post-surgery levels (P = 0.293). There were no differences in ANGPTL-4 change among groups. Triglycerides and HDL-cholesterol, as expected, improved as well after surgery. Correlations were found between ANGPTL-4 and improvement in HDL-cholesterol (r = –0.48, P = 0.028).
Conclusion
Plasma ANGPTL-4 is markedly elevated in women with severe obesity and 7 years after bariatric surgery it decreases to levels comparable to control lean subjects, in parallel with triglycerides and HDL-cholesterol improvement. These findings suggest that ANGPTL-4, mainly derived from adipose tissue, could be an important mediator of lipid improvement after bariatric surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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