ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
IL-18 in the Glucose Continuum
Iveta Nedeva 1 , Antoaneta Gateva 1 , Yavor Assyov 1 , Vera Karamfilova 1 , Tsvetelina Velikova 2 , Kyosuke Yamanishi 3 , Zdravko Kamenov 1 & Haruki Okamura 3
1Medical university Sofia, Internal Medicine, Sofia, Bulgaria; 2Medical university Sofia, Sofia, Bulgaria; 3Hyogo College, Japan
Background
Both obesity and diabetes are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. The aim of the present study was to investigate the circulating levels of IL-18 in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetes
Methods
IL-18 levels were determined using a commercially available human enzyme-linked immune sorbent assay (ELISA) kit.
Results
The sample consisted of 388 subjects with mean age 53.3 ± 10.78 years, divided in three age and BMI matched groups-obesity, prediabetes and diabetes. The control group consisted of 42 healthy individuals. IL-18 levels were significantly higher in patients with obesity and/or prediabetes and newly diagnosed diabetes compared to the control group respectively (249.77 ± 89.96; 259.01 ± 95.70; 340.98 ± 127.65 vs. 219.47 ± 110.53, P < 0.05). Correlation analysis showed that the level of IL-18 positively correlated with BMI, waist, WSR, VAI, liver enzymes, fasting and post load plasma glucose and insulin, uric acid, TG and negatively with HDL. ROC analysis determined circulating IL-18 levels to be of value for differentiating subjects with carbohydrate disturbances and those with MS. The AUC for carbohydrate disturbances was 0.597 (P = 0.001; 95%CI 0.539–0.654) and for MS AUC was 0.581(P = 0.021; 95% CI 0.516–0.647).
Conclusion
The levels of IL-18 were increased in patients with obesity and carbohydrate disturbances. Further studies will elucidate the role of this cytokine in development of type 2 diabetes and its complications.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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