Endocrine Abstracts

AimsNon-alcoholic fatty liver disease (NAFLD) is emerging as a public health issue worldwide, is highly prevalent in patients with type 2 diabetes (T2D), and is linked to obesity, insulin resistance and atherogenic dyslipidemia. We aimed to evaluate effects of testosterone therapy (TTh) on morphology and grade of NAFLD in obese men with functional hypogonadism (FH) and T2D.Research design and methods55 obese ...

IntroductionAnorexia nervosa is a severe and potentially lethal eating disorder. We report hereby the cases of two female-to-male transsexual patients whose anorexia nervosa was promptly resolved when they started gender-affirming hormone therapy.MethodsReview of the patients’ clinical records and of the relevant literature.Case reportsA 15 year-old male tran...

Use of SGLT2 inhibitors are increasing worldwide due to its potential antihyperglycemic role. Additionally they have shown to be beneficial in reducing the cardiac and renal complications in diabetes. There are sporadic reports to show their effects on liver enzymes. We did a single centre, open label, prospective trial to evaluate the role of dapagliflozin on hepatic enzymes in diabetic patients with non alcoholic fatty liver disease (NAFLD). Abdominal sonography was used to ...

IntroductionGlucagon-like peptide-1 (GLP-1) plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, results from previous studies on the GLP-1 secretory responses in individuals with different glucose tolerance states remain controversial. This may be contributed by the heterogeneous characteristics of the patients recruited.AimTo examine whether GLP-1 secretion is affected...

IntroductionMetabolic compensation of patients with diabetes mellitus (DM) depends on psychosocial well-being and healthy lifestyle, both of which were influenced by the national lockdown in spring 2020 due to the SARS-CoV-2 pandemic. The goal of our study was to analyze the impact of Swiss national lockdown (17.3.2020–24.4.2020) on compensation of DM as expressed by the level of HbA1c.MethodsWe performe...

BackgroundDiabetes is a multi-systemic disorder and psychosocial stress is a contributor for glycaemic derangement and resulting complications. Covid-19 has bought psychological stress and restriction of activity for many. Psychological risk factors such as anxiety and depression have been associated insomnia and fluctuations in BP and blood sugar values. Shavasana and other relaxation techniques have long been shown to reduce the stress. This relaxation...

BackgroundNon-dipping of nocturnal blood pressure is common among people with type 2 diabetes (T2D) and hypertension. Although the mechanism underlying the blunted nighttime response is unclear, insulin resistance is thought to play a role.AimsThis study aims to identify the pattern of nocturnal dipping of blood pressure in patients with T2D from a Portuguese population and its association with micro...

Background and aimsMetabolic syndrome (MetS) is a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and dyslipidemia. The prevalence of MetS parallels the rise of obesity rate reaching pandemic proportions due to the increased consumption of high-calories-high-fat-high-carbohydrates low-fibers diet associated with a sedentary lifestyle. MetS is associated with a plethora of comorbidities as non-alcoholic fatty liv...