Endocrine Abstracts

BackgroundResistance to thyroid hormone (RTH) involves an altered tissue response to thyroid hormones. RTH is characterized by increased serum thyroid hormone (TH) levels with nonsuppressed serum thyroid-stimulating hormone (TSH) levels. Herein, we report a rare case of RTH with recurrent papillary thyroid carcinoma (PTC).Patient findingsA 38-year-old female patient was admited to outpatient clinic for the ev...

BackgroundPapillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasm. American Thyroid Association (ATA) guidelines don’t specify how to follow-up low-risk PTC patients not receiving radioiodine therapy (RAI) after total thyroidectomy (TT). Indeed, there is no consensus among authors regarding the interpretation of thyroglobulin (TG) levels and ultrasound neck (US) findings during follow-up in these settings.<p class="abst...

IntroductionRecent published studies suggest that the anatomical location of the thyroid nodule may be associated with different risks of malignancy. However, the results are still sparce and little consensual.AimTo evaluate the frequency of nodules on different locations of the thyroid gland and to determine whether their location correlates with different malignancy risks.Methods<...

IntroductionDiffuse optic techniques exploit the capability of penetration of near infrared light to investigate the properties and physiology of tissues. Based on this property, the LUCA device (Laser and Ultrasound Co-Analyzer of Thyroid nodules), a multi-modal device that combines two different diffuse optical techniques – time resolved and diffuse correlation spectroscopies – with ultrasound in the same transducer, has been developed with t...

BackgroundMany microRNAs (miRNA) have been proposed as promising molecular markers of papillary thyroid carcinoma (PTC). However, there are limited data on the correlation between miRNA expression, and neck lymph node metastasis. Analysis of miRNAs expression data may improve perioperative decision making for patients with PTC, specifically in identifying patients harboring neck lymph node metastases (LNM).Aim of the study<p cl...

BackgroundRecent knowledge implicates a differential expression of the insulin-like growth factor-1 (IGF-1) mRNA splice variants (i.e., IGF-1Ea, IGF-1Eb and IGF-1Ec) in cancerous tissues, implying possible specific roles of the encoded IGF-1 protein isoforms in cancer biology. In particular, there is growing evidence that IGF-1Ec isoform may plays a distinct biological role in various types of cancer. The aim of the present study was to investigate wheth...

IntroductionMultifocality is a common finding in papillary thyroid carcinoma (PTC), but its biological significance is not well established. In some cases not all foci present the same histological pattern.ObjectiveTo study the different histological patterns and molecular profiles of multifocal PTC (mPTC).Material and methodsAll patients with a confirmed diagnosi...

BackgroundAggressive variants of papillary thyroid carcinoma (PTC) have been described with increasing frequency and are associated with unfavorable clinical outcomes. However, limited data exists on the comprehensive genetic profile of these variants.MethodWe performed targeted next generation sequencing in 36 patients with aggressive variants of PTC and compared it to PTC from The Cancer Genome Atlas projec...