Endocrine Abstracts

IntroductionMaturity Onset Diabetes of the Young (MODY) affects 1–2% of diabetic patients. Subtype 5 (HNF1β mutation) is rare (~1% of all MODY subtypes) and extra-pancreatic manifestations are often present (chronic kidney disease (CKD), liver disease and/or genitourinary malformations).AimTo report and review confirmed MODY 5 cases in an Endocrinology Department.Meth...

IntroductionIndividuals with type 2 diabetes mellitus (T2DM) are at an increased risk of developing fractures, despite higher mean BMI and BMD. Recently, clinically relevant sub-groups of T2DM have been characterised using biomarkers of glycemic metabolism.AimCharacterise T2DM sub-groups in a population-based setting and test for differences in fracture risk.Methods<p class="abstext...

IntroductionThe MTNR1B gene encodes a receptor for melatonin, a hormone that controls biorhythms. The gene is expressed primarily in the brain, but also in human pancreatic cells. Genetic studies suggest that variability in the MTNR1B gene is one of the factors sought to influence the pathophysiology of type 2 diabetes mellitus (T2DM). The single nucleotide polymorphism rs10830963 shows the strongest association. Our aim was to compare ...

ObjectiveVERIFY demonstrated the long-term benefits of an early combination (EC) treatment strategy compared with initial metformin monotherapy (MET) followed by sequential intensification in a multiethnic population with newly diagnosed type 2 diabetes mellitus (T2DM). The results for European patients enrolled in VERIFY are presented.MethodsAdult patients with T2DM (≤2 years) and mild hyperglycaemia (...

Aim of the studyTo identify the factors predicting insulin need in women with Gestational Diabetes Mellitus (GDM).MethodsIt was a retrospective study conducted in the National Institute of Nutrition between January 2018 and January 2019. Pregnant women referred for the management of GDM were included (n = 1000).GDM was defined according to the World Health Organisation as a glucose intolerance of var...

The mean absolute relative difference (MARD) on CGM was reported with the various values approximately from 5% to 10%. The MARD in patients with type 1 diabetes was reported to be higher than that in patients with type 2 diabetes. Therefore, as one of the reasons why the reported MARD values varied, it cannot be denied that glycemic variability affects calibration accuracy. We examined relationships between calibration accuracy and glycemic variability on CGM. This is a prospe...

There is little information regarding inter-individual variability of accuracy for CGM and flash glucose monitor (FGM) sensors. We studied the possibility of inter-individual variability of accuracy for CGM and FGM sensors. This is a prospective study. During hospitalization, 10 patients with type 2 diabetes wore a CGM [iPro2] and FGM [FreeStyle Libre Pro] in parallel over 24 h while every pre- and post-prandial “venous blood glucose levels” (VBG) were measured and u...

Background and aimDiabetes is the leading cause of adult blindness due to retinopathy. Serum uric acid levels independently predict the development of micro vascular complications. In this study, we analyze the relationship between serum uric acid (SUA) levels with the development and the severity of diabetic retinopathy(DR) in patients with type 2 diabetes mellitus (T2DM).Patients and MethodsA total of 100 T...