Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition

ea0073oc7.1 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Circulating concentrations of TMAO is associated with all-cause mortality in subjects with Non-alcoholic fatty liver disease. Results from a dutch prospective cohort

Flores-Guerrero Jose L. , van Dijk Peter R. , Connelly Margery A. , Garcia Erwin , Navis Gerjan , Bakker Stephan J.L. , Dullaart Robin P.F.

ObjectiveDue to the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), it has become a global health challenge by being the most common cause of chronic liver disease. Recently, the microbiota has been linked to NAFLD, via altered bile acid and lipid metabolism. Whether serum Trimethylamine-N-oxide (TMAO), a gut microbiota-dependent metabolite, is associated with NAFLD and NAFLD health outcomes remains unclear. The aim was to investigate...

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ea0073oc7.2 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatocyte GH signaling regulates carbohydrate processing in a STAT5b-independent manner

Vázquez-Borrego Mari C. , Del Rio-Moreno Mercedes , Sarmento-Cabral André , Mariyah Mahmood , Cordoba-Chacon Jose , Puchowicz Rhonda , Kineman Rhonda

In the healthy liver, GH signals through multiple pathways to modulate hepatic function, with JAK2/STAT5b required to maintain circulating IGF1 levels. It has been previously reported that mice with developmental knockout of hepatocyte GHR, JAK2 or STAT5 develop steatosis associated with glucose intolerance, systemic insulin resistance and white adipose tissue (WAT) lipolysis. These changes are thought to be secondary to increased circulating GH, due to loss of IGF1 negative f...

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ea0073oc7.3 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Long-term glucocorticoids are associated with increased odds of metabolic syndrome after an intensive combined lifestyle intervention

Mohseni Mostafa , Van der Valk Eline S. , Lengton Robin , Savas Mesut , Rijke Yolanda De , Van den Berg Sjoerd A.A. , Van der Voorn Bibian , Van Rossum Liesbeth F.C

BackgroundLong-term glucocorticoids, as measured in scalp hair (HairGC), are associated with obesity and the metabolic syndrome (MetS). It is not known whether this represents a state of obesity or whether chronic hypercortisolism may influence the course or reversibility of obesity. In this study we longitudinally examine the relation between HairGC concentrations and metabolic syndrome parameters in patients with obesity who participate in a 1.5 year i...

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ea0073oc7.4 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liver GPR55 regulates NAFLD progression from steatosis to fibrosis

Fernández Uxía , Fernández Fondevila Marcos , González Rellán María Jesús , Da Silva Lima Natalia , Buque Xabier , González Rodríguez Marta , Delgado Teresa , Varela Rey Marta V , Eva Novoa , Tojo Marta , Marta Miguel , Diéguez Carlos , Diéguez Miguel , DiéguezMaría Luísa , Arrese Marco , García-Monzón Carmelo , Mato Jose , Aspichueta Jose , Nogueiras Rubén

Background and aimsG protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, its specific role in lipid metabolism in the liver and its contribution to the pathophysiology of non-alcoholic fatty liver disease (NAFLD) remains unknown.MethodWe...

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ea0073oc7.5 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatic O-GlcNAcylated-p53 as a hub integrating the glucose counterregulatory response and insulin-suppressed gluconeogenesis

González Rellán María Jesús , Fernández Fondevila Marcos , Fernández Paz Uxia , Rodríguez Amaia , Varela Rey Marta , Veyrat-Durebex Christelle , Seoane Samuel , Bernardo Ganeko , Fernando Lopitz Otsoa , Fernandez Ramos David F , Bilbao Jon , Iglesias Cristina , Müller David F , Herzig Stephan , Martinez Chantar Maria Luz , Perez Fernandez Roman , Lopez Miguel , Diéguez Roman , Maria Mato Jose , Millet Oscar , Coppari Roberto , Woodhoo Ashwin , Fruhbeck Gema , Nogueiras Pozo Rubén

Background and aimsGlucose homeostasis is essential for life. The liver is among the key tissues for maintaining an adequate metabolic homeostasis and its alterations are at the root of the pathogenesis of many disease states. A perfect balance between glucose production, mainly at the liver, and glucose consumption in different tissues, is provided by the action of insulin and counterregulatory hormones as glucagon, cortisol or catecholamines. There is ...

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ea0073oc7.6 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

NTCP is a new promising target for treatment of metabolic diseases: A proof of mechanism from double-blind phase I clinical trials of Hepalatide

Zhu Zhenzhen , Tang Xiaolu , Zhu Shanwei , Wang Lizhen , Gao Xian , Cai Fei , Zhang Li , Liu Hongli , Wei Zhenman

Bile acids (BAs) are potent signaling molecules that regulate glucose, lipid and energy homeostasis predominantly via farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor 5 (TGR5). Modulation of bile acid profiles might affect the treatment of metabolic diseases, indicating new possible therapeutic avenues. The sodium taurocholate co-transporting polypeptide (NTCP) plays a pivotal role in the enterohepatic circulation of bile salts as the main uptake transpo...

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Endocrine Abstracts

European Congress of Endocrinology 2021