Endocrine Abstracts

Endocrine disrupting chemicals (EDCs) produce adverse effects associated with numerous pathologies: neurological disorders, metabolic diseases, infertility and cancer for example. How EDCs interfere with the development of hormone-sensitive tissue is a major question in biology. In this study, we propose that the model of prostate organoids can be used to study the effects of EDCs on the development of the prostate gland. Indeed, the differentiation of adult stem cells (ASC) i...

Thyroid hormones are evolutionarily conserved iodine-containing regulators of metabolism and development (reviewed by Mullur et al. (2014)). A key process in synthesis of the effectors thyroxine and tri-iodothyronine is the uptake of iodide from the bloodstream into thyroid follicular cells by the sodium-iodide symporter channel (NIS) encoded by the solute-carrier gene SLC5A5. Perturbation of NIS activity by environmental chemicals can lead to rapid and potent changes...

BackgroundIn the 2002 outbreak of severe acute respiratory syndrome (SARS) a number of patients presented abnormalities in the thyroid functioning, neuroendocrine and calcium homeostasis. It was detected in autopsies from SARS Coronavirus (SARS-CoV) patients that the thyroid gland was significantly affected by the disease, with extensive injury and death of follicular and parafollicular cells. In the present SARS-CoV-2 pandemic some studies start to repo...

IntroductionCorticosteroids are included in the maintenance immunosuppressive regimen in most kidney transplant recipients. Studies evaluating the effect of chronic low-dose glucocorticoid treatment on the hypothalamic-pituitary-adrenal (HPA) axis and the metabolic profile of these patients are limited.AimThe objective of the study was to evaluate the metabolic effects and the alterations of HPA axis regulati...

IntroductionFollowing the onset of the COVID-19 pandemic in early spring 2020, there was a need to identify the burden of this infection on people with rare endocrine conditions. The European Registries For Rare Endocrine Conditions (EuRRECa) was launched in 2018 in collaboration with Endo-ERN, ESPE and ESE to support the needs of the wider endocrine community. The project consists of an e-reporting (e-REC) platform that allows monthly reporting of new c...

Fabry Disease (FD) is a rare X–linked metabolic storage disease characterized by a–galactosidase A deficiency and deficient lysosomal function. The patients suffer from diffuse organ manifestations due to the accumulation of the substrate globotriaosylceramide (Gb3), which are only partially reversed by the available enzyme replacement (ERT) therapies. Previous endocrinological studies in patients with FD included small patient numbers or focused on a certain organ...