Endocrine Abstracts

BackgroundVascular endothelial growth factor (VEGF) has been implicated in angiogenesis of papillary thyroid carcinoma (PTC). As VEGF expression is increased in PTC and even in lymphocytic thyroiditis (LT), we hypothesized that VEGF may play a role in the development of PTC in patients with LT. In order to find an association between VEGF and these disorders, we examined both the tumoral and adjacent tissues of PTC patients with and without LT.<p cla...

ObjectivesRearrangement involving one of the neurotrophic-tropomyosin receptor kinase (NTRK) genes belonging to the NTRK family represents a significant oncogenic event in thyroid cancer (TC). Recently, there has been a growing interest in testing and characterizing NTRK fusion genes because they are therapeutically targetable. This study aimed to determine a frequency, clinical and histopathological features of a large cohort ...

IntroductionThe most cost-effective, minimally invasive and accurate tool to discriminate benign from malignant thyroid nodules is a fine-needle aspiration biopsy (FNAB). However, 2%–24% of FNABs provide non-diagnostic results, which are a clinical challenge, particularly when this result is recurrent.AimTo determine the predictive factors for recurrent non-diagnostic FNAB in thyroid nodules.<p class...

ObjectiveIn BALB/c mice with GD model, the TSHR and ICAM-1 were targeted for treatment, and new approaches to GD targeted therapy were explored.MethodsThe siRNA targeting TSHR and the ICAM-1 mAb specifically binding ICAM-1 were designed and synthesized. Thirty GD model mice were randomly divided into siRNA treatment group, ICAM-1 mAb treatment group, and untreated GD group, with 10 mice in each group, and 10 ...

BackgroundArtificial intelligence algorithms can be used in classification of thyroid nodules to reduce subjectivity. External validation on images collected from different ultrasound machines and other institutions are vital before wider use of these algorithms. We retrospectively analyzed the performance of AIBx on thyroid nodules with surgically proven pathology.Materials and methodsPatients harboring thyr...

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...