ECE2021 Eposter Presentations Pituitary and Neuroendocrinology (32 abstracts)
Acromegaly: clinical and para-clinical study by gender
Marwa Jemaa , Nadia Khessairi , Wafa Grira , Yasmine Mouelhi , Meriem Yazidi & Melika Chihaoui
Rabta Hospital, Endocrinology, Tunis, Tunisia
Gender is a factor in clinical presentation, biological and morphological characteristics in certain types of pituitary adenomas. Concerning acromegaly, this influence is not well known. In our retrospective study of 32 patients, 12 women and 20 men, hospitalized in our department from 2002 to 2019, we have realized a comparative clinical, para-clinical, therapeutic and prognosis. The median age of women is 47 years, the same as that of men. The average duration of disease progression is similar in both sexes (2.8 years). Extremity hypertrophy affects 88% of women vs. 80% of men, dysmorphic syndrome: 100% vs 95%, arthralgias: 83% vs. 63%, sleep apnea: 85% vs. 60%, organomegaly: 75% vs. 56%, diabetes mellitus: 41% vs. 45%, hypertension: 58% vs. 40%, hypertrophy of the left ventricle: 54% vs. 42%. We found microadenomas in 10% of men, macroadenomas: 100% vs. 89%. Acromegaly was associated with hyperprolactinemia in 54% of woman vs 11% of men, and complicated by corticotroph insufficiency in 66% vs 87%, thyreotropic and gonadotropic insufficiency were slightly the same in both sexe. Complications are slightly similar in both sexes except for microadenomas which seems to be less frequent in the woman group and hyperprolactinemia which is more frequent in this group.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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