Endocrine Abstracts

Introduction

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with a prevalence of 8– 13% in women of reproductive age. Accumulating evidence suggests that vitamin D deficiency might have multiple impacts on the disease process ; and is involved in the pathogenesis of metabolic syndrom in PCOS. This notion is carried by the fact that the vitamin D receptor gene regulates about 3% of the human genome. The purpose of this study is to elucidate vitamin D status and the potential association with metabolic factors in polycystic ovarian syndrome patients followed-up in our center

Patients and methods

This is a retrospective data analysis of 51 PCOS patients, attending the endocrinology department of Oujda’s Mohammed VI university hospital. The levels of 25OHD in the serum were determined using Architect chemiluminescent immunoassay technology, and Insulin resistance was estimated by the HOMA-IR. For all statistical tests, P value below 0.05 was pictured as statistically significant

Results

A total of 51 patients were involved in the study. The mean age was 24.83 ± 5.62 years. The majority of PCOS subjects (69.2%) were found to be vitamin D deficient, ; with an average vitamin D concentration of 13.54 ± 7.14 ng/ml. Serum 25-hydroxyvitamin concentrations less than 10 ng/ml were classified as severe vitamin D deficiency and were found in 25% of cases. Overweight was noticed in 67.3% with a mean body mass index (BMI) of 26.12 ± 5.86 kg/m² and a mean waist circumference of 91.25 ± 17.61 cm. All PCOS patients underwent a 75-g oral glucose tolerance test, and the association between vitamin D status and HOMA-IR was statistically significant (P < 0.001), whereas the association between vitamin D status and BMI ranges was not statistically significant (P = 0.52). 25-hydroxyvitamin D concentrations were positively correlated with high-density lipoprotein cholesterol (P < 0.05).

Conclusion

Vitamin D deficiency is highly prevalent among women with PCOS, with an increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS syndrome. In order to prove these findings, large intervention trials with vitamin D supplementation are warranted in PCOS women.