Endocrine Abstracts

Metabolic syndrome (MS) is one of the most pressing problems of modern medicine. MS is a symptom complex of impaired carbohydrate metabolism, abdominal obesity, dyslipidemia, hypertension with an increased risk of developing cardiovascular diseases and type 2 diabetes mellitus. The main reasons for the increase in the incidence of MS are a decrease in physical activity and a high-calorie diet. The prevalence of MS in different countries is 25–30% and varies depending on the criteria used. The aim of our study was to assess the role of blood biochemical parameters in the diagnosis of MS. Materials and methods. 60 patients with MS and 45 apparently healthy volunteers were examined on the basis of the therapeutic department of the Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences. The glucose level was determined by the glucose oxidant method, the lipid profile was assessed using standard test systems. Insulin level was determined by enzyme immunoassay using the DRG test system. All examined persons signed an informed consent to participate in the study, approved by the ethics committee of the Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences. Statistical data processing was carried out using the Statistica for Windows 8.0 software packages with the determination of the median (Me) and interquartile range (C25–C75). The statistical significance of differences was determined using the Mann–Whitney rank test, P <0.05. Results In patients with MS, the HOMA-IR index increased by almost 2 times (P = 0.003) relative to the control group, which is a predictor of the risk of developing vascular and diabetic complications in them. The non-esterification fatty acids (NEFA) content was increased in all patients with MS (P = 0.001), while the NEFA value was 2 times higher than normal values ​​(P = 0.004). There was an increase in the content of insulin (P = 0.002) and glucose (P = 0.003) in the fasting blood in patients with MS in comparison with the control group. Conclusion The study confirmed that early diagnosis of vascular and diabetic complications in patients with MS requires a combined determination of the HOMA-IR index and the content of NEFA. These indicators were sensitive in all patients with MS.