Systemic diseases and diabtes

Imen Chabchoub; Mouna Elleuch; Faten Hadj Kacem; Salah Dhoha Ben; Nadia Charfi; Nabila Mejdoub; Fatma Mnif; Mouna Mnif; Abid Mohamed

doi:10.1530/endoabs.73.EP75

Introduction

The association of type 1 diabetes with other autoimmune diseases is well known due to a common genetic terrain of varied clinical expressions. However, the occurrence of systemic diseases in diabetic patient, whatever the type of diabetes, is poorly studied. The objective of this study is to describe autoimmune and inflammatory diseases associated with diabetes.

Materials and methods

It ’ s a retrospective, descriptive study of the observations of diabetic patients followed up in our department, who have been diagnosed with an associated systemic disease based on clinical, immunological and/or histological data.

Results

We involved 22 patients: 20 women and 2 men with an average age of 49.9 years at the time of diagnosis of diabetes. They were type 2 diabetes in 19 cases (86.3%), type 1 diabetes in 1 case (4.5%), corticosteroid-induced diabetes: 1 case and gestational diabetes: 1 case. The discovery of diabetes is made in front of polyuropolydipsia in 14 cases, weight loss in 6 cases and fortuitous in 3 cases. Oral antidiabetic drugs (OADs) were prescribed in 18 patients and insulin therapy was immediately initiated in 3 cases. Metabolic syndrome was noted in 41% of patients. Vascular complications of diabetes were noted in 68% of cases. Associated systemic diseases were Rheumatoid Arthritis: 12 cases (54.5%), Sjogren’s Syndrome: 4 cases (18%), Hashimoto’s autoimmune thyroiditis: 2 cases (9%). Primary biliary cirrhosis, Horton’s disease, Behçet’s disease, antiphospholipid syndrome and Still’s disease were objected in 1 case respectively. Diabetes preceded the systemic disease in 8 cases for an average duration of 11 years, succeeded it in 8 cases for an average duration of 11 years and occurred concomitantly in 6 cases. Diabetes was unbalanced at the time of relapses of the systemic diseases in 81.8% of cases.

Conclusion

Each of the two pathologies can influence the evolutionary course of the other, while underlining the effect of the outbreaks of systemic diseases on the imbalance of diabetes by the inflammation they generate or by the prescribed therapeutics.

Endocrine Abstracts

EP75