Endocrine Abstracts

Introduction

Primary thyroid lymphomas (LTP) are a rare entity, characterized by their histological and clinical heterogeneity. They represent 5% of thyroid tumors and 2% of extra-ganglionic lymphomas. We report two observations of LTP by specifying the epidemiological, diagnostic and therapeutic features.

Observations

Observation 1

70-year-old patient, followed in internal medicine for Sd sec, having undergone a total thyroidectomy in 2004 with diffuse large B-cell anapathic malignant lymphoma (LMNH) on LMNH of MALT associated with a lymphocytic thyroiditis. The patient benefited from 4 chemotherapy sessions (CHOP), with Levothyrox 100 µg/day put on. Complete remission was obtained with a normal cervical ultrasound.

Observation 2

68-year-old patient with no particular history, in particular no thyreopathy, thyroidectomized in 2016 with a histological appearance compatible with a Hodgkin’s lymphoma scleronodular form, the immunohistochemical study showed an intense and diffuse positivity of tumor cells to antibodies anti-CD15 and anti-CD30, the patient received 6 courses of chemotherapy (ABVD protocol) and radiotherapy on the tumor bed, the patient currently on Levothyrox 100 µg/day with clinical and radiological monitoring.

Conclusion

Despite its rarity and unusual location, lymphoma of the thyroid gland must be known and taken into account in the differential diagnosis of thyroid tumors. Early diagnosis and management allow favorable treatment results to be obtained.