ECE2021 Audio Eposter Presentations Reproductive and Developmental Endocrinology (55 abstracts)
Primary ovarian failure: descriptive study of 50 cases
Wajdi Safi 1 , Mouna Elleuch 2 , Dhouha BenSalah 1 , Hamdi Frikha 1 , Nadia Charfi 1 , Nabila Rekik 1 , Fatma Mnif 1 , Mouna Mnif Feki 1 , Faten Hadj Kacem 1 & Mohamed Abid 1
1Hedi Chaker hospital, Sfax; Tunisia, Sfax, Tunisia, Department of Endocrinology, Sfax, Tunisia
Introduction
Primary ovarian failure currently represents an increasingly frequent cause for consultation in endocrinology, from 4 to 18 % of the causes of primary amenorrhea and 10 to 28 % of the causes of secondary amenorrhea.
Objectives
In this context, we report a retrospective study of 50 patients followed between 2000 and 2020 for early menopause, in order to assess the etiologies and risk factors favouring this pathology as well as its subsequent impact.
Results
The average age of our patients was 31 years with extremes ranging from 10 years to 40 years. A family history of early menopause was noted in only 6% of women. The reason for consultation was secondary amenorrhea in 52% of cases followed by primary amenorrhea in 32%. In our study we found that the majority of women are nulliparous, in 68% of cases. The diagnosis was confirmed by an average FSH level of 87.25 mIU/l, LH at 28.45 mIU/l, the average E2 value was 2.4 pg/ml and the average prolactin value was 29.02ng/ml The study showed that the main aetiology was premature autoimmune ovarian failure in 58% of cases, a congenital cause in 24% of cases, and chemotherapy and radiotherapy are involved in 6% of cases. All the women in our survey presented complications following their menopause, of which 70% presented short-term complications, mainly sleep disorders, hot flashes and urinary genital disorders, 20% of the women presented metabolic complications at medium term and long term and 48% of women presented mainly cardiovascular complications.
Conclusion
Hormone replacement therapy is necessary to avoid the increased risk of all these complications, especially osteoporosis and cardiovascular complications. If you want to become pregnant, in vitro fertilization with oocyte donation is currently the most effective technique
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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