ECE2021 Audio Eposter Presentations Pituitary and Neuroendocrinology (113 abstracts)
Value of cross- sectional area of the median nerve in acromegalic patients
Ivana Ságová 1 , Dušan Pavai 1 , Daniela Kantárová 2 , Dana Holováčová 3 , Milan Dragula 2 , Juraj Payer 4 & Peter Vaňuga 1
1National institute of Endocrinology and Diabetology, Ľubochňa, Slovakia, Department of endocrinology, Ľubochňa, Slovakia; 2Comenius University Jessenius Faculty of Medicine, 1st Department of Internal Medicine, University Hospital Martin, Martin, Slovakia, Martin, Slovakia; 3Comenius University Faculty of Medicine, 1th Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia, Bratislava, Slovakia; 4Comenius University Faculty of Medicine, 5th Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia, Bratislava, Slovakia;
Introduction
Median nerve neuropathy is commonly associated with acromegaly.
Objective
This study aims to investigate ultrasound examination of median nerve in acromegalic patients and assess the relationship with activity and duration of disease.
Patients and methods
We prospectively examined the cross sectional area (CSA) of median nerve with high-resolution ultrasound in 107 acromegalic patients (70 females and 37 males) and in 77 healthy controls (51 females and 26 males) matched for age, gender. The t-student tests and Pearson correlation were used for data analysis.
Results
The cross sectional area of median nerve was increased in acromegalic patients compared with controls (11.9 ± 0.5 mm2 vs 7.8 ± 0.3 mm2, P < 0.001). The average level of IGF-1 in acromegaly patients was ø 249, 9ng/ml and for GH was ø 2, 63 ng/ml. Positive correlation between was found the levels of IGF-1 and CSA in whole study group (R = 0.400, P < 0.001) and female population (R = 0.466, P < 0.001). In male population our results did not reach statistical significace (P = 0.07). Relationship between CSA and duration of acromegaly in both genders was not confirmed.
Conclusion
In our study we confirmed the enlargement of the median nerve in acromegaly patients. This enlargement is proportional to the degree of IGF-1 levels and is not dependent on the duration of the disease and age of patients.
Keywords: acromegaly, carpal tunnel syndrome, cross sectional area, median nerve.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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