ECE2021 Audio Eposter Presentations Late Breaking (114 abstracts)
Papillary thyroid microcarcinomas that metastasize to lymph nodes
Ahmet Dirikoc 1 , Abbas Ali Tam 1 , Nurcan Ince 1 , Didem Ozdemir 1 , Oya Topaloglu 1 , Afra Alkan 2 , Aylin Kılıcyazgan 3 , Reyhan Ersoy 1 & Bekir Cakır 1
1Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Ankara, Turkey; 3Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Pathology, Ankara, Turkey.
Background
We aimed to determine clinicopathological features that can predict lymph node metastasis (LNM) in papillary thyroid microcarcinomas (PTMC).
Methods
Medical records of 872 patients with papillary thyroid cancer >1 cm (PTC >1 cm) and 1184 patients with papillary thyroid microcancer (PTMC) (£1 cm) were reviewed retrospectively. Demographical, clinical and histopathological features of (PTC >1 cm) and PTMC were compared. Association between clinicopathological features and LNM in PTMC was investigated.
Results
The median age of patients with PTMC was significantly higher than patients with PTC>1 cm (49 vs 46 years old, P <0.001). Multifocality, capsular invasion, vascular invasion, extrathyroidal extension (ETE) and LNM were more frequent in patients with PTC>1cm compared to patients with PMTC (P <0.001 for each). In PTMC group, those with LNM had significantly higher proportion of multifocality, capsular invasion, vascular invasion and ETE compared to those without LNM (P = 0.007, <0.001, P = 0.011 and P <0.001, respectively). Multifocality and ETE were significant factors for LNM with logistic regression analysis. Multifocality increased the risk of LNM by 1.737 times (95% CI: 1.079–2.979) and ETE increased the risk by 3.528 times (95%: 1.914–6.503). Primary tumor diameter ≥5.75 mm was predictive for LNM with a sensitivity of 0.782 and a specificity of 0.517 in PTMC.
Conclusion
LNM should be investigated more carefully in patients with PTMC in the presence of tumor diameter≥5.75 mm, multifocality or ETE.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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