Endocrine Abstracts

Introduction

Modern diabetology is focused on preventing late complications of diabetes and to find research tools to detect discrete changes, with the possibility of early entry with treatment. Type 1 diabetes (DM1) causes oxidative stress, affects the cardiovascular system and increases vascular stiffness. The non-invasive measurement of central blood pressure (CBP) together with augumentation and aplification indicators, more accurately reflects the condition of blood vessels and can be useful in monitoring patients with DM1.

Aim

Evaluation of central blood pressure parameters in children with DM1

Materials and methods

The study was conducted in 101 children selected for age, weight and height, without hypertension (mean age 13 years). They were divided into a control group (A) of healthy children (n = 21) and patients with DM1 with short <5 years ((B) n = 37) and long > 5 years ((C) n = 43) duration of the disease, under the care of the Diabetes Clinic and the Department of Pediatrics, Endocrinology and Diabetology udsk in Bialystok. Based on HbA1c levels, all DM1 patients were divided into 2 groups with good HbA1c <7.5% (D) and insufficient HbA1c > 7.5% (E) metabolic control. Three CBP measurements were taken at 5-minute intervals using the Centron Diagnostic and then averages were calculated. The statistical analysis was performed using the Stat12.5 (U Mann-Withney test).

Results

Peripheral and central blood pressure were comparable in patients with type 1 diabetes mellitus and control group. The Augumentation rate was significantly higher in children with DM1 who had short-term patients (0.62 vs 0.56, P = 0.02). Statistical significance was not demonstrated in cbp parameters between groups of children with diabetes mellitus, while both vascular stiffness indicators showed a positive trend with regard to vascular elasticity in the group of children with DM1 long-suffering (AUG 0.62 vs 0.58, AMP 1.65 vs 1.76). In patients with HbA1c, >7.5% hba1c correlates with CBP.

Conclusions

Vascular stiffness rates of Augumentation and Aplification showed improvement during therapy and were higher in the group of children with DM1<5 years, perhaps as a residue after ketoacidosis at the time of diagnosis of the disease. Significant vascular changes may not occur early in DM1 in children with good metabolic control.