ECE2021 Audio Eposter Presentations Late Breaking (114 abstracts)
New biomarkers to predict cardiovasculer risk in patients with adrenal incidentaloma; irisin and nesfatin-1
Mustafa Can 1 , Muhammet Kocabas 1 , Mellia Karakose 1 , Yakup Alsancak 2 , Fatma Hümeyra Yerlikaya Aydemir 3 , Hatice Çalışkan Burgucu 1 , Ilker Cordan 4 , Cengiz Kadıyoran 5 , Mustafa Kulaksizoglu 1 & Feridun Karakurt 1
1Meram Tıp Fakültesi Hastanesi, Department of Endocrinology and Metabolism, Turkey; 2Meram Tıp Fakültesi Hastanesi, Department of Cardiology, Turkey; 3Selçuk Üniversitesi Tıp Fakültesi Mediko Sosyal, Department of Biochemistry, Turkey; 4Edirne Sultan Murat 1. State Hospital, Department of Endocrinology and Metabolism, Turkey; 5Meram Tıp Fakültesi Hastanesi, Department of Radiology, Turkey
Objectives
Evidence from recent studies suggests that patients with adrenal incidentaloma have increased cardiovascular risk. In our study, we aimed to investigate the levels of irisin, nesfatin-1 and the relationship between levels of these relatively new molecules with cardiometabolic risk markers; carotid intima-media thickness (CIMT), epicardial adipose tissue (EAT) thickness and abdominal subcutaneous adipose tissue (SCAT) thickness in patients with nonfunctional adrenal incidentaloma (NFAI).
Methods
Patients with NFAI (n = 59) and age-, sex- and body mass index-matched healthy control subjects (n = 59) were enrolled in this study. Serum glucose, insulin, C-reactive protein (CRP), lipid, irisin and nesfatin-1 levels were measured in patients and controls. In addition, echocardiographic CIMT and EAT thickness measurements of patients and controls were made.
Results
The irisin level was 17.58 ± 4.38 pg/ml in the NFAI group and 14.03 ± 4.03 pg/ml in the control group, and it was significantly higher in the NFAI group (p < 0.001). Nesfatin-1 level was 194.98 ± 119.15 pg/ml in the NFAI group and 303.48 ± 200.78 pg/ml in the control group, and it was significantly lower in the NFAI group (P < 0.001). There were no difference between two group in terms of CIMT and EAT thickness (P > 0.05) Positive correlations were found between irisin level and CIMT (r: 0.384, p: 0.003) and EAT thickness (r: 0.333, p: 0.010) in the NFAI group. In addition, positive correlations were also found between nesfatin-1 level and CIMT (r: 0.323, p: 0.013) and EAT thickness (r: 0.292, p: 0.025) in the NFAI group.
Conclusions
In our study, we found that irisin level was higher and nesfatin-1 level was lower in patients with NFAI, and both irisin and nesfatin-1 levels were associated with CIMT and EAT thickness in NFAI patients. Irisin and nesfatin-1 can be used as markers to predict the cardiovasculer risk in patients with NFAI.
Keywords: nonfunctional adrenal incidentaloma, irisin, nesfatin-1, carotid intima-media thickness.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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