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Endocrine Abstracts (2021) 73 AEP412 | DOI: 10.1530/endoabs.73.AEP412

1Università ’Federico II’ di Napoli, Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Napoli, Italy; 2ASL Napoli 3 Sud, Consultorio InConTra, Portici (NA), Italy; 3Università ’Federico II’ di Napoli, Dipartimento di Studi Umanistici, Sezione di Psicologia Clinica, Napoli, Italy; 4Università ’Federico II’ di Napoli, Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Sezione di Psichiatria, Napoli, Italy; 5Università ’Federico II’ di Napoli, Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Sezione di Psicologia Clinica, Napoli, Italy


During 2020 spring, national lockdown was adopted in Italy to prevent COVID-19 pandemic spread. Restrictive measures, including lockdowns, were associated with impaired psychological outcome, mainly increased perceived stress and anxiety, in general population. As transgender people (T*) are associated with higher prevalence of perceived stress, anxiety, and depression, higher psychological vulnerability during lockdowns cannot be excluded. The aim of the PICARD study was the evaluation of psychological impairment in T* during the COVID-19-related Italian national lockdown, as compared with healthy subjects. The study enrolled 112 T* (41 T* women, 71 T* men; age: 18–55 yrs) and 224 age- and gender-matched cisgender controls. General Anxiety Disorder-7 (GAD7), Perceived Stress Scale (PSS), and Patient Health Questionnaire 9 (PHQ9) questionnaires (higher scores indicated higher psychological impairment) were telematically and anonymously administered to study participants during the last three weeks of national lockdown to screen their general anxiety, perceived stress, and depression status levels. Demographic, social, and clinical information were also collected. Compared with cisgender controls, T* experienced significantly higher scores in GAD7, PSS, and PHQ9 questionnaires (P < 0.001). In particular, T* men experienced significantly higher scores in all questionnaires (P < 0.001), whereas no significant differences were observed between T* and cisgender women. In the T* population, higher GAD7, PSS, and PHQ9 scores were contemporary observed in T* < 25 vs > 35 yrs (P < 0.001), T* without name change vs ongoing (P < 0.01), T* with no gender-affirming surgeries versus reconstructive surgeries (P < 0.02), and T* suffering from lockdown-related domestic violence vs who did not (P < 0.04). Higher GAD7 and PSS scores were contemporary observed in unemployed vs employed T*(P ≤ 0.05), whereas higher PSS and PHQ9 scores were contemporary observed in T* living with their parents vs alone (P < 0.02) and with partner (P < 0.03). Isolated higher PSS scores were observed in T* not performing vs performing hormonal treatments (P < 0.001). In conclusion, compared with cisgender controls, T* suffered increased psychological morbidity, namely general anxiety, stress perception, and depressive status, during Italian national lockdown. In particular, younger T*, unemployed T*, T* still living with their parents, and T* in the earliest stage of their transitional process (i.e. without birth name change, hormonal treatments, or gender-affirming surgeries) were more psychologically vulnerable. Therefore, empowerment of psychological counseling for T* during COVID-19 pandemic should be considered by health care services.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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