Endocrine Abstracts

The aim of the study is the search of predictors of the development of androgen deficiency in men with 1 diabetes mellitus type 2. The study included 243 men with type 2 diabetes mellitus aged 35–55 years. The median age of men was 39.00 [30.00; 45.00] years, the median duration of diabetes mellitus type 2 was 12.00 [7.00; 22.00] years. As a result of the research, it was found that an increase in the patient’s age significantly increased the risk of developing androgen deficiency (b = 0.07, Exp (b) = 1.08 (1.00 ÷ 1.16), P < 0.05). The age of smoking experience also had a significant effect on the risk of developing androgen deficiency (b = 0.06; Exp (b) = 1.07 (1.10 to 1.13), P < 0, 04). The relative risk of developing (RR) androgen deficiency in men with a smoking experience of more than 7 years was 3.76 and was statistically significant (95% CI = 1.07 ÷ 13.25). With an increase in the level of glycated hemoglobin, the risk of developing androgen deficiency also increased significantly (b = 0.08; Exp (b) = 1.01 (1.00 ÷ 1.02), P < 0.04). The exceeding of the glycated hemoglobin level above 7.5% demonstrated a statistically significant RR = 6.71 (95% CI = 1.19 ÷ 37.86). The reduction of LDL decreased the risk of developing androgen deficiency in the men surveyed at the level of a stable trend (b = –0.45; Exp (b) = 0.64 (0.35 ÷ 1.18), P < 0.10). At an LDL level of less than 3.50 mmol/l, the RR of androgen deficiency was 0.29 and was statistically significant (95% CI = 0.09 to 0.97). The rise in VLDL significantly increased the risk of androgen deficiency (b = 0.71; Exp (b) = 2.04 (1.11 ÷ 3.76), P < 0.02). At a VLDL level of 0.42 mmol/l, the RR was 2.58 (95% CI=1.38 to 3.29). As can be seen from the data provided, unsatisfactory compensation of type 2 diabetes mellitus increases the risk of developing androgen deficiency in men.