ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Role of sarcopenia in cognitive function in patients with morbid obesity before bariatric surgery
Andreu Simó-Servat 1 , Montserrat Ibarra 1 , Mireia Libran 1 , Maite Valverde 1 , Veronica Perea 1 , Luis García-Pascual 1 , Aida Orois 1 , Carmen Quirós 1 , Laura Casas 2 & Maria Jose Barahona Constanzo 1
1Universitari Mutua de Terrassa, Endocrinology, Terrassa, Spain; 2Hospital Universitari Mutua de Terrassa, Neurology, Terrassa, Spain
Aim
Obesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Additionally, sarcopenic obesity (SO) was associated independently with a deterioration in global cognition, executive function, information processing speed, global memory and cerebral atrophy in patients > 65 years. However, at present there is no data regarding the role of sarcopenia in the cognitive function in patients with morbid obesity (MO) < 65 years.
Material and methods
Cross-sectional study. Forty-three patients that will undergo Y-de- Roux gastric by-pass were selected from those attended at the MO Unit of our hospital. Body composition by bioimpedance analysis (BIA) and Neurocognitive Test Battery (NTB) were assesed in all patients 1 month prior bariatric surgery (BS). For identifying subjects with SO by BIA, we used the skeletal muscle mass index (SMI) (SM/height2). We set that obese subjects from the lowest tertile of SMI were sarcopenic whereas those from the two highest tertiles were not.
Results
Thirteen patients were allocated in the SO group and 26 in the non-SO group. All patients in the SO group were female (100% vs 58%), older (59 ± 5 vs 51 ± 8 years), with lower BMI (41 ± 1.3 vs 45 ± 5 kg/m2), higher fat mass (%) (50 ± 4 vs 43 ± 8) and lower claw force by hand dynamometer (21 ± 4.5 vs 31.5 ± 10) (P < 0.005). SO group had worse performance (raw score) in inverse visual span [3(2–5) vs 4(3–7)], Trail Making Test A [47(32–99) vs 38(15–98)], Trail Making Test B [133(74–300) vs 86(36–300)] and Symbol Digit Test (31 ± 13 vs 42 ± 13) (P < 0.005). No differences were observed in educational level between both groups. The 4 cognitive tests correlated with age (P < 0.005). After regression analysis, age and the presence of SO significantly correlated with Trail Making Test B and Symbol Digit Test, but only was the inverse visual span test that correlated with SO (β 0.459, P < 0.05), losing the correlation with age.
Conclusions
Sarcopenia could play a role in impaired executive function and information processing speed in a cohort of patients with MO < 65 years. Larger series are needed in order to confirm this preliminary results.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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