Endocrine Abstracts

Aim

Diabetic cardiomyopathy (DC) is congestive heart failure developed in diabetic patients, without coronary, hypertensive, valvular nor myocardial alcoholic disease. Aim of this stady was to confirm if presence of diabetic autonomic neuropathy (DAN) is correlating with development of DC in patients with diabetes.

Methods

We have evaluated 90 examinees: 30 of them with diabetes type 1(T1D), 30 with diabetes type 2 (T2D) and 30 healthy examinees that were in control group. With all examinees we have performed cardiovascular dynamic tests and echocardiography – one-dimensional, two-dimensional and doppler on Aloca 830 machine. Parasympathetic function was tested with 3 cardiovascular reflexes tests (Valsalve maneuver, deep breathing test, stand-up after lying position test), and sympathetic function with 2 tests (orthostatic hypotension test, and hand grip test).

Results

Results have showed that systolic function of left chamber (LC) in T1D patients with DAN was normal in 90.5%, and pathological in 9.5% (P < 0.01), and in T2D patients with DAN was normal in 76.7%, and pathological in 23.3% (P < 0.01). LC diastolic function in T1D patients with DAN was normal in 46.7%, and pathological in 52.4% (P > 0.05). In T2D patients with DAN, diastolic function of LC was impaired in 83.3% (P < 0.01).

Conclusion

DAN is significantly increased in patients with T2D. Within those patients, diastolic function of LC was impaired significantly more frequent, until systolic function was non-affected in both of these diabetes types. Correlation between LC diastolic function impairment and DAN could signify its possible spot in diabetic cardiomyopathy etiopathogenesis.