Endocrine Abstracts

Background

Cardiovascular autonomic neuropathy (CAN) is a chronic complication associated with high risk of cardiovascular morbidity and mortality either in patients with diabetes mellitus and prediabetes. However, risk factors of CAN in patients with prediabetes and coronary artery disease (CAD) was not fully investigated.

Aims

The aim of this study was to investigate risk factors of CAN in patients with prediabetes and CAD.

Materials and methods

We examined 32 patients with prediabetes and angiography confirmed stenosis of coronary arteries, 20 males and 12 females (aged 61.44 ± 1.92 years, HbA1c – 5.87 ± 0.1%) (data are presented everywhere as mean ± sem). All patients were performed cardiovascular autonomic reflex tests (CARTs) by Ewing. The diagnosis of CAN was confirmed in patients with 2 and more positive tests. The statistical analysis was performed using SPSS statistical package version 25.0 for Windows.

Results

CAN detected by 2 abnormal tests of CARTs was diagnosed in 40.6% patients with prediabetes and CAD, by 3 abnormal tests – in 43.8%. We found positive correlation between the total score of CARTs: and levels of total cholesterol, (r = 0.44, P < 0.05), fasting insulin, (r = 0.41, P < 0.05), HOMA-IR (r = 0.46, P < 0.01), heart rate (r = 0.4, P < 0.05), and negative correlation with glomerular filtration rate, (r = –0.39, P < 0.05). We found that CAN diagnosed by 2 abnormal tests of CARTs had positive correlation with fasting glucose, (r = 0.36, P < 0.05) and HbA1c (r = 0.4, P < 0.05), but if there was no correlation of CAN detected by 3 abnormal tests of CARTs with these parameters.

Conclusion

CAN is the common complication of prediabetes and there are some risk factors for its development revealed in our study.