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Endocrine Abstracts (2021) 73 AEP136 | DOI: 10.1530/endoabs.73.AEP136

1Bone Metabolic Unit, Endocrinology and Nutrition Division. Universitary Hospital Clínico San Cecilio., Granada, Spain; 2Hospital Pharmacy Division. Universitary Hospital Clínico San Cecilio., Granada, Spain


Context

The incidence of Type 2 diabetes mellitus (T2DM) is increasing and muscle strength and function are reported to be decreased in patients with T2DM compared to healthy controls.However, the relation between bone and muscle remain unclear.

Objective

Our aims was to examine bone health parameters [by Dual energy X-ray absorptiometry (DXA) and trabecular bone score (TBS)] and muscle strength (by hand grip) in T2DM patients.

Design

Cross-sectional observational study

Setting

Tertiary care hospital

Patients

60 T2DM patients (60% males and 40% postmenopausal women) aged 49–85 years.

Measures

Anthropometric and metabolic parameters were determined. Bone mineral density (BMD) of the lumbar spine(LS), femoral neck(FN) and total hip(TH) and TBS were assessed using DXA and TBS iNsight Software. Hand grip strength (kg/cm2) was measured with a jamar hydraulic hand dynamometer (5030j1; jackson, MI).Handgrip strength < 30 kg (male) or < 20 kg (female) was defined as low muscle strength. Data were analysed using SPSS 25.0.

Results

60 patients with T2DM were studied. Mean age of T2DM patients was 66.3 ± 8.31 years. Mean HbA1C was 7.7 ± 1.1%. 73.3% had poorly glycemic control ( HbA1c > 7.5%).95.8% of female and 91.7% of male had low muscle strength.Hand-grip strength was positively correlated with TBS (R = 0.321, P < 0.01) and with TH- BMD (R = 0.268, P < 0.05).

Conclusions

Our study show that the reduction of muscle strength was significantly associated with decreased bone mass and deteriorated bone microarchitecture in T2DM patients.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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