Endocrine Abstracts

Introduction

Some studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, and there appears to be a minor role in the acute phase of AMI. In fact, triglyceride fatty acids are the main source of energy, LDL appears to be critical for cell membrane synthesis and both are essential for cell synthesis.

Material and methods

In an attempt to demonstrate whether total cholesterol (TC), LDL, a high density lipoprotein (HDL) and TG can influence Killip’s classification, as well as early post-AMI mortality, we reviewed the clinical processes of patients with type 1 diabetes. 2 admitted by EAM to our hospital. We performed a statistical analysis using SPSS version 25.0. A value of P < 0.05 was considered statistically significant.

Results

In a total of 129 patients with type 2 diabetes, they were admitted to our hospital with AMI. Of these, 65.9% were male and their ages vary between 35 and 90 years, with an average age of 68.27 ± 10.71 years. The median HbA1c at admission was 7.5% (AIQ = 1.5). Of the sample, 18.6% had current smoking habits, 20.9% had previous smoking habits and 21.7% had chronic kidney disease. Regarding other co-morbidities, we verified the occurrence, in most patients, of arterial hypertension (86%) and overweight / obesity (72.9%). TG levels were lower in those who died compared to those who survived beyond 30 days (P = 0.04), however there was no association between this and patients classified as high Killip compared to patients with low Killip (P = 0.75). As for the level of TC, LDL and HDL, its influence on early mortality and Killip’s classification was not found. High Killip severity was associated with in-hospital mortality in 30 full days (P = 0.013).

Conclusion

Lower levels of TG were related to a higher rate of early mortality. The small sample size may have constituted a bias, impeding the demonstration of a relationship between LDL and the other variables under study. Other studies with more patients need to be carried out to clarify these data.