BES2020 BES 2020 Sex differences in association between gestational weight gain and neonatal adiposity: boys are at higher risk (1 abstracts)
Sex differences in association between gestational weight gain and neonatal adiposity: boys are at higher risk
De Landtsheer Anaïs ¹ , Benhalima Katrien ¹ , Van Crombrugge Paul 2 , Moyson Carolien ¹ , Verhaeghe Johan ³ , Verlaenen Hilde 4 , Vercammen Chris 5 , Maes Toon 5 , Dufraimont Els 6 , De Block Christophe 7 , Jacquemyn Yves 8 , Laenen Annouschka 9 , Devlieger Roland 3 , Minschart Caro 1 & Mathieu Chantal 1
¹Department of Endocrinology, University hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; 2Department of Endocrinology, OLV ziekenhuis Aalst-Asse-Ninove, Moorselbaan 164, 9300 Aalst, Belgium; 3Department of Obstetrics & Gynecology, University hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; 4Department of Obstetrics & Gynecology, OLV ziekenhuis Aalst-Asse-Ninove, Moorselbaan 164, 9300 Aalst, Belgium; 5Department of Endocrinology, Imelda ziekenhuis, Imeldalaan 9, 2820 Bonheiden, Belgium; 6Department of Obstetrics & Gynecology, Imelda ziekenhuis, Imeldalaan 9, 2820 Bonheiden, Belgium; 7Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, Wilrijkstraat 10, 2560 Edegem, Belgium; 8Department of Obstetrics & Gynecology, Antwerp University Hospital and Global Health Institute GHI Antwerp University, Wilrijkstraat 10, 2650 Edegem, Belgium; 9Center of Biostatics and Statistical bioinformatics, KU Leuven, Kapucijnenvoer 35 bloc d –box 7001, 3000 Leuven, Belgium
Aims: To determine predictors of neonatal adiposity and differences in associations by fetal sex in women with gestational diabetes mellitus (GDM), normal-weight and overweight (BMI ≥ 25 kg/m²) normal glucose tolerant women (NGT).
Methods: Skinfold thickness was measured in 576 newborns, and cord blood leptin, c-peptide and lipids in 327 newborns in a multi-centric prospective cohort study.
Results: Compared to neonates of normal-weight NGT women (327), neonates of women with GDM (97) were at higher risk of being large-for-gestational age (LGA) (16.5% vs 8.6%, P = 0.024) but the macrosomia rate (8.2% vs 5.8%, P = 0.388), sum of skinfolds (13.9 mm ± 2.9 vs 13.3 mm ± 2.6, P = 0.067), neonatal fat mass (1333.0 g ± 166.8 vs 1307.3 g ± 160.9, P = 0.356), and cord blood biomarkers were not significantly different. Compared to neonates of normal-weight NGT women, neonates of overweight NGT women (152) had higher rates of macrosomia (12.5% vs 5.8%, P = 0.012), LGA (17.1% vs 8.6%, P = 0.006), higher sum of skinfolds (14.3 mm ± 2.6 vs 13.2 mm ± 2.6, P < 0.001), neonatal fat mass (1386.0 g ± 168.6 vs 1307.3 g ± 160.9, P < 0.001), % neonatal fat mass > 90th percentile (15.2% vs 7.1%, P < 0.001), without significant differences in cord blood biomarkers. Maternal BMI, fasting glycaemia, insulin resistance, triglycerides, gestational weight gain, cord blood leptin and cord blood triglycerides were independent predictors for neonatal adiposity. Gestational weight gain was positively associated with adiposity in boys only.
Conclusions: Compared to neonates of normal-weight NGT women, neonates of GDM women have higher LGA rates but similar adiposity, while neonates of overweight NGT women have increased adiposity. Limiting gestational weight gain might be especially important in the male fetus to reduce neonatal adiposity.
Volume 71
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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