Endocrine Abstracts

There have been raising concerns in the effects of endocrine disrupting chemicals like triclosan (TCS) on the embryo development. Triclosan (TCS) is commonly present in household and personal wash products We hypothesize that exposure to TCS during early stage of development could alter brain development affecting behavior. To test this hypothesis, primary cortical neurons were exposure to TCS with/without estrogen antiestrogen ICI 182780 from day in vitro 1 to 4. We also address whether maternal TCS-exposure at dose 10 mg/kg and 100 mg/kg during pregnancy and lactation, affects neurobehavioral development in the offspring generation. We found that TCS impaired to growths of dendrite and axon by reducing the average dendrite lengths and number of both axon and dendrite. In the present of ICI, the effects of TCS on neurite growth are recued. At six weeks of age, the spatial learning and reference memory in offspring derived from dams exposed to TCS were impaired. Furthermore, TCS-treated groups displayed cognition dysfunction in novel test and impairments in sociability and social novelty preference in three-chamber social test. In addition, TCS-treated groups increased anxiety-like behavior in open field test. Moreover, TCS-treated groups exhibited deficits in nesting behavior. However, there was no significant difference in depression-like behavior in tail suspension test and forced swimming test. Our data demonstrate that perinatal exposure to TCS induces the neurodevelopment disorder, causes abnormal in social behavior, cognitive impairment, and deficits in spatial learning and memory in offspring.