ECE2020 Oral Communications Hot Topics (including COVID-19 (7 abstracts)
Experimental induced autoimmune thyroiditis in wistar rats: possible protective role of selenium
Ioana Vasiliu 1 , Delia-Gabriela Ciobanu-Apostol 2,3 , Ioana Armasu 4 , Ionela Lacramioara Serban 4 , Dragomir N Serban 4 , Ovidiu Bredetean 5 , Cristina Oprisa 4 , Luiza Pohaci-Antonesei 4 , Manuela Stefan 4 & Cristina Preda 6,7
1“Grigore T. Popa” University of Medicine and Pharmacy, Department of Physiology, IASI, Romania; 2“Grigore T. Popa” University of Medicine and Pharmacy, Morphopathology, IASI, Romania; 3“Sf. Spiridon” County Hospital, Pathology, IASI, Romania; 4“Grigore T. Popa” University of Medicine and Pharmacy, Physiology, IASI, Romania; 5“Grigore T. Popa” University of Medicine and Pharmacy, Pharmacology, IASI, Romania; 6“Grigore T. Popa” University of Medicine and Pharmacy, Endocrinology, IASI, Romania; 7’’Sf. Spiridon’’ County Hospital, Endocrinology, IASI, Romania
Experimental autoimmune thyroiditis (EAT) has been used to simulate human autoimmune thyroid disease for decades. EAT can be easily induced in genetically susceptible strains of mice by excess iodine ingestion or by immunization with mouse thyroglobulin. Excess iodine may induce and exacerbate autoimmune thyroiditis (AIT) in humans and animal models. In order to assess the potential protective mechanisms of selenium (Se) in thyroid autoimmunity, we evaluated the effects of inorganic Se (sodium-selenite) administration on thyroid morphology and follicular cytology in adult Wistar rats with iodine-induced AIT. Forty-eight adult Wistar rats (24 females, 24 males) were allocated to one of four dietary regimens: C0: control; C1: only potassium-iodine (KI); C2: concomitant KI and Se; C3: only KI initially, followed by Se administration. For AIT induction, the rats were fed with 0.05% KI for 56 days. Se-treated rats received 0.3 mg/l sodium-selenite in drinking water. Thyroid tissue for pathologic diagnosis was collected after 7 days in C0, 56 days for C1 and C2, and 112 days in C3. In C1, moderate to severe thyroiditis was observed in 83% males and 50% of female rats (P = 0.223). In C3 only, 16.7% of male rats developed mild thyroiditis and none in C2, while no females were identified with moderate to severe thyroiditis in both C2 and C3. The male rat thyroid morphology showed that the C1 group had higher mean values of thyroid follicles compared to C0, the control group (73.82 µm vs 50.13 µm, ×100), and to the C2 (73.82 µm vs 53.74 µm, × 100). In female rats, the highest mean value of thyroid follicles was recorded in C1 group (57.56 µm, × 100), and the lowest in C2 (47.32 µm, ×100). Thus, the administration of Se was proved to have protective effects against thyroiditis cytology in both male and female Wistar rats.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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