Endocrine Abstracts

Introduction: Gougerot disease is an autoimmune disorder characterized by the lymphoid infiltration of salivary and lachrymal glands leading to the two most common symptoms dry eyes and a dry mouth. Primary hyperparathyroidism (PHPT), one of the most common endocrine disorders, is usually diagnosed by the association of hypercalcemia and parathyroid hormone (PTH) levels that are either elevated or inappropriately normal. The association of PHPT with Gougerot disease is rare, only few cases were reported in the literature. Herein we report the case of a female patient diagnosed with PHPT and Gougerot Disease.

Observation: A 60-year-old woman with no past medical history was admitted to our department to explore hypercalcemia and renal failure. The aboratory investigations revealed severe hypercalcemia (3.6 mmol/l), hypophosphatemia (0.54 mmol/l), and elevated PTH level (569 pg/ml). Cervical ultrasonography showed no parathyroid lesion but sestamibi sintigraphy reveled a voluminous left superior parathyroid adenoma. A surgical treatment of the parathyroid adenoma was then performed. However, the patient complained of dry eyes and a dry mouth of few month of duration. The diagnosis of Gougerot disease was confirmed by the association of xerostomy; anti-SSa- and anti-SSb-positive, and Chisholm stage IV lymphocytic sialadenitis. The etiological investigation confirmed a primary Gougerot disease.

Conclusion: The association between PHPT and Gougerot disease is reported in literature but up to date no etiopathogenetic links between the two affections were found.