Endocrine Abstracts

Introduction: Chronic inflammation is an important factor in type 2 diabetes and cardiovascular diseases development. Studies demonstrate that body fat, estimated by anthropometric indicators, correlates with inflammation indicators in chronic diseases. Ipso facto, it seems reasonable to suppose, that there would also be a correlation between anthropometric parameters and both, old and new inflammation indicators in patients with non-functioning adrenal incidentalomas.

Aim: The aim of the study was to evaluate anthropometric parameters and indicators – waist circumference (WC), BMI, WHR, WHtR, BAI, VAI, LAP, BRI, ABSI, RFM and its relationship with inflammation indicators – old one: insulin, CRP and new one: PLR (platelet–lymphocyte ratio), MPVLR (MPV-to-lymphocyte ratio), SII (systemic immune–inflammation index) in group of patients with non-functioning adrenal incidentalomas.

Material and Methods: The study included 182 patients with non-functioning adrenal incidentalomas hospitalized in Endocrinology City Hospital in Piekary in 2014–2018. The exclusion criteria were mainly: other adrenal disorders, decompensated diabetes defined as HBA1 C% >7, kidney failure as eGFR<60 ml/min per 1.73 m², liver failure as bilirubin>2 mg/dl, INR>1.5 and albumins<3.5 g/dl, severe inflammation, treated cancer disease. Biochemical parameters (taken from the patient’s medical record) and anthropometric measurements were used to calculate anthropometric indicators. Patients were also analyzed with electrical bioimpedance to estimate percentage of body fat and visceral fat rate.

Results: The average age in studied group was 63 years, cortisol concentration at 0800 h was 12.05 µg/dl, CRP was 3.7 mg/l, insulin 12.8 µU/ml. There strongest correlation (P<0.05) was observed between insulin and: BRI (r = 0.58), WHtR (r = 0.58), BMI (r = 0.58), RFM (r = −0.58). VAI correlated negatively (P<0.05) with MPVLR (r = −0.25) and PLR (r = −0.17), BAI with SII(r = −0.2). There was a positive correlation between CRP and BRI (r = 0.16) as well as WC (r = 0.16).

Conclusion: New anthropometric indicators, especially VAI and BRI, are more useful in the assessment of potential inflammation in studied group of patients with non-functioning adrenal incidentalomas, than the previous ones.