ECE2020 ePoster Presentations Bone and Calcium (65 abstracts)
Is hip geometry modified in acromegalic patients?
Elena Alexandru 1 , Patricia Christina Codreanu 1 , Theodor-Eugen Oprea 1,2 , Irina Nistor 1 , Raluca Pascu 1 , Florina Andrada Predescu 1 , Niculina Giurgiuman 3 , Sorina Martin 1,2 , Anca Sarbu 1,2 , Alice Albu 1,2 , Simona Fica 1,2 & Carmen Gabriela Barbu 1,2
1Endocrinology, Elias Emergency University Hospital, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 3Elias Emergency University Hospital, Bucharest, Romania
Introduction: Besides the amount of bone mineral assesed through bone mineral density (BMD), studies have shown that neck geometry parameters as hip axis length (HAL) and neck-shaft angle (NSA) could also be reliable parameters to be included in the hip fracture assesement. On the other hand, bone geometry is known to be modified in acromegaly in flat bones, thus hip fracture is not a recognized direct complication in acromegaly neither through bone mass or long bone geometry.
Objectives: The aim of the study is to evaluate hip axis length (HAL) and neck-shaft angle (NSA) in acromegaly compared with same parameters in non-acromegalic patients.
Methods: There were analyzed examinations of DXA of the proximal femur from 19 patients with acromegaly with a mean age of 59 years compared with the same number of examinations from 19 non-acromegalic patients with a mean age of 55 years. The data was collected from the authors database retrospectively. The independent Samples t-test was used to investigate the relationships between acromegaly and HAL and also NSA. Mean HAL value was significantly greater in acromegalic patients versus control group (116.1 mm vs 104.8 mm; P<0.01). Mean NSA in acromegalic group didn’t show any significant difference compared with non-acromegalic patients (53.63 mm vs 54.84 mm).
Results: With the limitations of the small sample of patients, our study showed a significantly greater HAL in acromegalic patients, which has been associated with a higher hip fracture risk. Considering that no significant difference was found regarding NSA, our results support an increased hip fracture risk in acromegalic patients versus non-acromegalic patients based on a modified hip geometry inspite of known exposure at GH excess in adulthood only.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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