Endocrine Abstracts

The aim of investigation: To study neurological characteristics of patients with type 1 and type 2 diabetes who received hemodialysis

Material and research methods: We for the period from January, 01.2017 to December, 31, 2017 year 102 patients with type 1 and type 2 diabetes mellitus were examined. Of these, men – 45 (44.1%), women – 57 (55.9%). Average age: men amounted to 57.12 years, women – 58.15 years. 20 of them were urgently received hemodialysis. The research methods included: 1) general clinical (study of endocrine, neurological status, anthropometry 2) instrumental (fundus, visual acuity, ECG, densitometry, Ultrasound of internal organs and dopplerography of the main arteries of the head, etc.), 3) biochemical tests (Hb1AC, glycemic profile, urea, creatinine, lipid spectrum, coagulogram),4) hormonal blood tests (insulin, C-peptide etc.)

Research results: Depending on the degree of diabetic encephalopathy, all observed patients were divided into 3 groups:1 gr – 23 patients with diabetic nephropathy of 4–5 stages with CBI 1 st (chronic brain ischemia); 2 gr. – 45 patients with diabetic nephropathy of 4–5 stages with CBI 2 st; 3 gr. – 34 patients with diabetic nephropathy of stages 4–5 with CBI 3 st.

Analysis of neurological status showed various disorders. Patients of the 1st group had headaches, noise in the head, memory loss, and in the neurostatus the disappearance of surface reflexes, anisoreflexia. Patients of the 2nd group experienced headaches, noise in the head, memory loss, depression, sleep disturbances, attacks of transient ischemic attacks, and the appearance of pathological Babinsky symptoms from 2 sides was characteristic in the neurostatus. In the 3 group of patients, we observed a history of stroke in 5 cases (14.7%), in neurostatus hemiparesis in 5 patients(14.7%), dysarthria – 4 cases (11.7%), pseudo-bulbar syndrome – 6 patients (17.6%), increased muscle tone in spastic and plastic type – 11 patients (32.3%).

Conclusions: 1) Among the examined 102 patients, patients with a 2 degree of chronic cerebral ischemia prevailed; 2) Severe neurostatus disorders were detected in patients of group 3.