Endocrine Abstracts

GABA from medical nutrition to pancreatic beta-cell regeneration.

Introduction: Type 1 diabetes is considered as one of the most widespread chronic diseases in the world, which happens due to autoimmune damage of beta cells in islets of langerhans in the pancreas. It is the most widespread type of diabetes in young age below 18 years(1.2).The beginning or progress of autoimmune cellular injury of pancreatic beta cells could occur through the presence of many auto-antigens which are detected in the pancreatic beta cells(12).it was found that GABA promoting proliferation of beta cells which may have good impact on type 1diabetes(21).

Design: Randomized, controlled trial, 6 month trial.

Materials and Methods: 100 type 1 diabetes patients were randomized into 2 groups.

Result: The results exhibited a statistically significant decrease of anti-gad antibodies and a statistically significant increase of c peptide levels after 6 months of treatment with GABA.

Conclusion: GABA may be used for decreasing anti-gad antibodies and beta-cell regeneration.