Endocrine Abstracts

Introduction: Parathyroid gland proliferative disorders include adenoma, hyperplasia and carcinoma. Adenoma and hyperplasia are found more commonly in women, while carcinoma, which is very rare, is found in both sexes equally. The aim of this study was to investigate parathyroid gland tumors surgically removed at University Hospital Centre Osijek between 2016 and 2019. Also to review tumor location, size and histopathology and compare sex difference.

Patients and Methods: Patients of both sexes undergoing parathyroidectomy for parathyroid gland tumor in University Hospital Centre Osijek between 2016 and 2019 were included in the study. Parathyroid gland tumor samples were histologically analyzed, their size and histopathology were noted. Existing documentation on patients with parathyroid gland tumor was used. Analyses was done on archived histologic material stained with hematoxylin – eosin stain. Statistical analysis was done on MedCalc Statistical Software version 18.9.

Results: Overall 19 samples of parathyroid gland tumor were included in this study. Tumors of the parathyroid glands are most commonly localized on the lower left parathyroid (8 cases, 42%), and most rarely on the upper right (2 cases, 11%). The histopathological diagnosis was most commonly determined by adenoma (11 cases, 58%), followed by hyperplasia, while no cancer was diagnosed. Tumors were operated more frequently on women than on men (17 vs 2 cases). There was no correlation in histopathology of parathyroid tumor and sex (Fisher’s Exact Test, P = 1). And there was also no correlation in tumor location and sex (Fisher’s Exact Test, P = 1).

Conclusion: The most common locations of tumors of the parathyroid glands were the lower glands, the more frequent was the lower left parathyroid and most often it was an adenoma. Women are more frequently operated on than men.

Keywords: parathyroid glands, primary hyperparathyroidism, histopathology, staining and labeling