Endocrine Abstracts

Aim: To assess the thyroid and reproductive system status in 222 women with normal menstrual cycles.

Material and Methods: Patients were referred for thyroid ultrasonography and concurrent breast ultrasonography. The 160 women were divided into two groups, based on the nature of the thyroid pathology.

Results: The 1st group included 90 women with autoimmune thyroiditis (AIT), the median age was 36.00 [25.00; 50.00] years, the 2nd group – 70 women with nodular goiter, median age was 37.00 [31.00; 45.00] years. Women with AIT showed inverse significant correlations between age and testosterone level (ρ = –0.32; P < 0.001), age and DHEAS level (ρ = –0.38; P = 0.001), as well as BMI and FT₄ (ρ = –0.24; P = 0.04). Direct significant correlations were established between progesterone and estradiol levels (ρ = 0.30; P = 0.01), progesterone and FT₃ levels (ρ = 0.24; P = 0.04). Testosterone had a direct significant correlation with the FT₃ level (ρ = 0.24; P = 0.04). DHEAS level had a direct significant correlation with the TSH level (ρ = 0.33; P = 0.004). Prolactin levels also had a direct significant correlation with estradiol levels (ρ = 0.23; P < 0.05). Age had a direct significant correlation with BMI (ρ = 0.50; P = 0.001). In the group of women with nodular goiter, age had an inverse significant correlation with progesterone levels (ρ = –0.37; P = 0.002); testosterone levels (ρ = –0.39; р = 0.002) and DHEAS levels (ρ = –0.47; P < 0.001). An inverse significant correlation was established between progesterone and FSH levels (ρ = –0.32; P = 0.01). In this group, a direct correlation was established between age and prolactin level (ρ = 0.31; P = 0.01) and BMI (ρ = 0.53; P < 0.001). The progesterone and testosterone levels had a direct significant correlation (ρ = 0.36; P = 0.004).

Conclusion: The obtained results indicate that the presence of thyroid pathology can be considered as one of the risk factors for the development of mastopathy.