Endocrine Abstracts

Background: Increasing of the level of circulating Antithyroid autoantibodies suggested about autoimmune destruction in thyroid gland and not always depends from thyroid status. We aimed to study the frequency of circulating antithyroid autoantibodies (ATAB) in people with the different thyroid diseases.

Material and Methods: In 25 people with high level of circulating ATAB blood serum TSH, T3, T4, glucose, ALAT, protein, albumin levels were measured. Thyroid gland ultrasound and ECG were performed. HR and BP were assessed.

Results: According to thyroid function in 64% were determined euthyreosis (TSH 1.6 ng/ml), in 24% with hyperthyroidism (TSH 0.1 ng/ml) and 12% with hypothyroidism (TSH 15.4 ng/ml). The average levels of ATAB were comparable between the groups and were four times higher than in healthy subjects. There were no significant differences in blood Calcium, Phosphorus level and alkaline phosphatase activity, whereas blood total protein, albumin, ALAT levels were oppositely linked with thyroid function. Interestingly, higher level of ATAB were accompanied with impaired glycemia in 56% patients with ecthyreosis, in 17% with hyperthyrosis and no glycemia impairments were detected in patients with hypothyreosis.

Conclusion: In patients with higher circulating ATAB mostly detected euthyreosis (in 64%) than hyperthyreosis (in 24%) and hypothyreosis (in 12%). In people with higher ATAB the glycemia impairments were determined in those with euthyreosis (56%) and hyperthyreosis (17%).